NPPB

Entrez Summary: N/A
UniProt Summary: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. {ECO:0000269|PubMed:1672777}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rapamycin 0.001μM R08 exp429	-1.85
Calcium Ionophore 0.4μM R07 exp342	1.96

diuretic hormone activity
hormone receptor binding
receptor guanylyl cyclase signaling pathway
cGMP biosynthetic process
positive regulation of renal sodium excretion
positive regulation of urine volume
cGMP metabolic process
negative regulation of systemic arterial blood pressure
regulation of renal sodium excretion
regulation of urine volume
cyclic nucleotide biosynthetic process
cyclic purine nucleotide metabolic process
regulation of excretion
cGMP-mediated signaling
regulation of renal system process
regulation of vascular permeability
cyclic nucleotide metabolic process
negative regulation of blood pressure
body fluid secretion
regulation of systemic arterial blood pressure
hormone activity
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
neuropeptide signaling pathway
renal system process
negative regulation of vasculature development
regulation of blood vessel diameter
regulation of tube diameter
regulation of tube size
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
vascular process in circulatory system
purine-containing compound biosynthetic process
cyclic-nucleotide-mediated signaling
regulation of blood pressure
negative regulation of cell growth
protein folding
negative regulation of growth