NPR3

Entrez Summary: This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011].
UniProt Summary: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. {ECO:0000250|UniProtKB:P70180}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

natriuretic peptide receptor activity
osteoclast proliferation
pancreatic juice secretion
hormone binding
chloride ion binding
positive regulation of urine volume
negative regulation of adenylate cyclase activity
negative regulation of cyclase activity
secretion by tissue
positive regulation of nitric-oxide synthase activity
regulation of urine volume
negative regulation of lyase activity
regulation of osteoblast proliferation
positive regulation of monooxygenase activity
regulation of adenylate cyclase activity
G protein-coupled peptide receptor activity
peptide hormone binding
regulation of cyclase activity
regulation of nitric-oxide synthase activity
regulation of lyase activity
negative regulation of smooth muscle cell proliferation
negative regulation of cold-induced thermogenesis
peptide binding
positive regulation of oxidoreductase activity
regulation of monooxygenase activity
phosphatidylinositol-mediated signaling
digestive system process
body fluid secretion
inositol lipid-mediated signaling
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
phospholipase C-activating G protein-coupled receptor signaling pathway
regulation of oxidoreductase activity
leukocyte proliferation
renal system process
digestion
regulation of smooth muscle cell proliferation
regulation of cold-induced thermogenesis
regulation of blood pressure
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger