NPS

Entrez Summary: N/A
UniProt Summary: Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440). {ECO:0000250, ECO:0000269|PubMed:15312648, ECO:0000269|PubMed:16790440}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of circadian sleep/wake cycle, wakefulness
regulation of circadian sleep/wake cycle, wakefulness
positive regulation of action potential
positive regulation of synaptic transmission, GABAergic
positive regulation of circadian rhythm
regulation of circadian sleep/wake cycle
positive regulation of behavior
regulation of synaptic transmission, GABAergic
positive regulation of synaptic transmission, glutamatergic
visual learning
regulation of action potential
visual behavior
regulation of synaptic transmission, glutamatergic
regulation of behavior
associative learning
neuropeptide signaling pathway
regulation of circadian rhythm
learning
positive regulation of synaptic transmission
learning or memory
cognition
response to light stimulus
regulation of membrane potential
response to radiation
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
behavior
response to abiotic stimulus
G protein-coupled receptor signaling pathway
nervous system process
positive regulation of multicellular organismal process
positive regulation of cell communication
positive regulation of signaling
extracellular region
system process