NR1H2 [The Human Chemical-Genetic Interaction Map Project]

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======= NR1H2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NR1H2
  * **<color #00a2e8>Official Name</color>**: nuclear receptor subfamily 1 group H member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7376|7376]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55055|P55055]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NR1H2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NR1H2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600380|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Nuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). {ECO:0000250|UniProtKB:Q60644, ECO:0000269|PubMed:25661920}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hormone recep|
|zf-C4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|apolipoprotein A-I receptor binding|
|negative regulation of pinocytosis|
|negative regulation of interferon-gamma-mediated signaling pathway|
|negative regulation of response to interferon-gamma|
|negative regulation of cholesterol storage|
|positive regulation of lipoprotein lipase activity|
|positive regulation of triglyceride lipase activity|
|regulation of pinocytosis|
|positive regulation of triglyceride biosynthetic process|
|negative regulation of macrophage derived foam cell differentiation|
|regulation of cholesterol storage|
|positive regulation of cholesterol efflux|
|regulation of triglyceride biosynthetic process|
|positive regulation of fatty acid biosynthetic process|
|negative regulation of lipid storage|
|positive regulation of triglyceride metabolic process|
|regulation of lipoprotein lipase activity|
|positive regulation of cholesterol transport|
|regulation of cholesterol efflux|
|positive regulation of sterol transport|
|regulation of response to interferon-gamma|
|regulation of interferon-gamma-mediated signaling pathway|
|negative regulation of lipid transport|
|regulation of macrophage derived foam cell differentiation|
|positive regulation of fatty acid metabolic process|
|regulation of triglyceride metabolic process|
|negative regulation of lipid localization|
|negative regulation of endocytosis|
|regulation of fatty acid biosynthetic process|
|regulation of lipid storage|
|regulation of cholesterol transport|
|regulation of sterol transport|
|nuclear receptor activity|
|negative regulation of cold-induced thermogenesis|
|steroid hormone receptor activity|
|negative regulation of innate immune response|
|negative regulation of cytokine-mediated signaling pathway|
|positive regulation of lipid transport|
|negative regulation of response to cytokine stimulus|
|nuclear receptor transcription coactivator activity|
|positive regulation of lipase activity|
|RNA polymerase II transcription factor complex|
|transcription regulatory region sequence-specific DNA binding|
|positive regulation of lipid biosynthetic process|
|cholesterol homeostasis|
|ATPase binding|
|sterol homeostasis|
|positive regulation of lipid localization|
|regulation of fatty acid metabolic process|
|negative regulation of response to biotic stimulus|
|regulation of lipase activity|
|regulation of lipid transport|
|steroid hormone mediated signaling pathway|
|lipid homeostasis|
|regulation of lipid localization|
|positive regulation of small molecule metabolic process|
|positive regulation of lipid metabolic process|
|regulation of cold-induced thermogenesis|
|negative regulation of immune response|
|intracellular receptor signaling pathway|
|regulation of cytokine-mediated signaling pathway|
|hormone-mediated signaling pathway|
|regulation of cellular ketone metabolic process|
|regulation of response to cytokine stimulus|
|transcription initiation from RNA polymerase II promoter|
|cellular response to lipopolysaccharide|
|regulation of lipid biosynthetic process|
|cellular response to steroid hormone stimulus|
|cellular response to molecule of bacterial origin|
|signaling receptor activity|
|regulation of endocytosis|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|cellular response to biotic stimulus|
|DNA-templated transcription, initiation|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|response to steroid hormone|
|transcription factor binding|
|negative regulation of response to external stimulus|
|regulation of lipid metabolic process|
|sequence-specific DNA binding|
|regulation of small molecule metabolic process|
|negative regulation of immune system process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of innate immune response|
|transcription by RNA polymerase II|
|negative regulation of transport|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|cellular response to organic cyclic compound|
|regulation of vesicle-mediated transport|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|response to bacterium|
|negative regulation of cellular component organization|
|negative regulation of cell differentiation|
|regulation of defense response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|zinc ion binding|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|response to hormone|
|response to organic cyclic compound|
|negative regulation of developmental process|
|positive regulation of transport|
|cellular response to oxygen-containing compound|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|regulation of immune response|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.96|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.81|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.46|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:abcg1|ABCG1]]|0.427|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12973
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NR1H2 Expression in NALM6 Cells: 4.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>