NR2F6

Entrez Summary: N/A
UniProt Summary: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). {ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:10713182, ECO:0000269|PubMed:11682620, ECO:0000269|PubMed:18701084}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

zf-C4
Hormone recep

detection of temperature stimulus involved in sensory perception of pain
detection of temperature stimulus involved in sensory perception
detection of temperature stimulus
entrainment of circadian clock by photoperiod
sensory perception of temperature stimulus
photoperiodism
entrainment of circadian clock
nuclear receptor activity
steroid hormone receptor activity
sensory perception of pain
RNA polymerase II distal enhancer sequence-specific DNA binding
regulation of circadian rhythm
detection of external stimulus
steroid hormone mediated signaling pathway
detection of abiotic stimulus
intracellular receptor signaling pathway
hormone-mediated signaling pathway
transcription initiation from RNA polymerase II promoter
response to temperature stimulus
cellular response to steroid hormone stimulus
DNA-templated transcription, initiation
DNA-binding transcription repressor activity, RNA polymerase II-specific
response to light stimulus
RNA polymerase II regulatory region sequence-specific DNA binding
response to steroid hormone
sequence-specific DNA binding
response to radiation
transcription by RNA polymerase II
cellular response to lipid
cellular response to organic cyclic compound
detection of stimulus involved in sensory perception
cellular response to hormone stimulus
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
detection of stimulus
neuron development
zinc ion binding
response to lipid