NRK

Gene Information

Official Symbol: NRK
Official Name: Nik related kinase
Aliases and Previous Symbols: N/A
Entrez ID: 203447
UniProt: Q7Z2Y5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010].
UniProt Summary: May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18543
Expression level (log2 read counts): -1.4

Expression Distribution

CNH
Pkinase Tyr
Pkinase

regulation of cell proliferation involved in embryonic placenta development
regulation of spongiotrophoblast cell proliferation
activation of JNKK activity
parturition
activation of MAPKK activity
actin cytoskeleton reorganization
positive regulation of JUN kinase activity
JNK cascade
regulation of JUN kinase activity
stress-activated MAPK cascade
regulation of embryonic development
positive regulation of JNK cascade
stress-activated protein kinase signaling cascade
regulation of reproductive process
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
regulation of JNK cascade
multi-multicellular organism process
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
positive regulation of MAP kinase activity
activation of protein kinase activity
regulation of developmental growth
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
protein serine/threonine kinase activity
MAPK cascade
signal transduction by protein phosphorylation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
actin cytoskeleton organization
cell part morphogenesis
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of MAPK cascade
actin filament-based process
positive regulation of kinase activity
positive regulation of transferase activity
neuron projection development