NRP1 [The Human Chemical-Genetic Interaction Map Project]

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======= NRP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NRP1
  * **<color #00a2e8>Official Name</color>**: neuropilin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8829|8829]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14786|O14786]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NRP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NRP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602069|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MAM|
|DUF3481|
|F5 F8 type C|
|CUB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cytokine activity|
|VEGF-activated neuropilin signaling pathway involved in axon guidance|
|otic placode development|
|VEGF-activated neuropilin signaling pathway|
|dorsal root ganglion morphogenesis|
|endothelial tip cell fate specification|
|positive regulation of retinal ganglion cell axon guidance|
|ganglion morphogenesis|
|renal artery morphogenesis|
|vestibulocochlear nerve structural organization|
|blood vessel endothelial cell fate commitment|
|hypothalamic tangential migration using cell-axon interactions|
|cerebral cortex tangential migration using cell-axon interactions|
|angiogenesis involved in coronary vascular morphogenesis|
|blood vessel endothelial cell fate specification|
|facioacoustic ganglion development|
|basal dendrite morphogenesis|
|protein localization to early endosome|
|endothelial cell fate specification|
|sensory neuron axon guidance|
|gonadotrophin-releasing hormone neuronal migration to the hypothalamus|
|basal dendrite arborization|
|basal dendrite development|
|hypothalamus gonadotrophin-releasing hormone neuron differentiation|
|regulation of cytokine activity|
|hypothalamus cell migration|
|neuropilin signaling pathway|
|sympathetic neuron projection guidance|
|trunk neural crest cell migration|
|ventral trunk neural crest cell migration|
|sympathetic neuron projection extension|
|hypothalamus gonadotrophin-releasing hormone neuron development|
|trunk segmentation|
|trigeminal ganglion development|
|trigeminal nerve morphogenesis|
|trigeminal nerve structural organization|
|regulation of retinal ganglion cell axon guidance|
|substrate-dependent cerebral cortex tangential migration|
|dichotomous subdivision of terminal units involved in salivary gland branching|
|motor neuron migration|
|axonogenesis involved in innervation|
|sorting endosome|
|neural crest cell migration involved in autonomic nervous system development|
|cranial ganglion development|
|branchiomotor neuron axon guidance|
|kidney vasculature morphogenesis|
|positive regulation of axon extension involved in axon guidance|
|endothelial cell fate commitment|
|regulation of Cdc42 protein signal transduction|
|vestibulocochlear nerve morphogenesis|
|renal system vasculature morphogenesis|
|vascular endothelial growth factor-activated receptor activity|
|vascular endothelial growth factor binding|
|dendrite arborization|
|dorsal root ganglion development|
|neuron projection extension involved in neuron projection guidance|
|blood vessel endothelial cell differentiation|
|positive regulation of axon guidance|
|neurofilament|
|axon extension involved in axon guidance|
|hypothalamus cell differentiation|
|endothelial cell chemotaxis|
|facial nerve structural organization|
|sympathetic ganglion development|
|cerebral cortex tangential migration|
|coronary artery morphogenesis|
|retina vasculature morphogenesis in camera-type eye|
|dichotomous subdivision of an epithelial terminal unit|
|vestibulocochlear nerve development|
|substrate-dependent cell migration, cell extension|
|positive regulation of receptor binding|
|facial nerve morphogenesis|
|neuron projection arborization|
|cranial nerve structural organization|
|facial nerve development|
|semaphorin receptor complex|
|trigeminal nerve development|
|protein localization to endosome|
|hepatocyte growth factor receptor signaling pathway|
|ectodermal placode development|
|semaphorin receptor activity|
|commissural neuron axon guidance|
|semaphorin-plexin signaling pathway involved in axon guidance|
|semaphorin-plexin signaling pathway involved in neuron projection guidance|
|epithelial cell fate commitment|
|coronary vasculature morphogenesis|
|ganglion development|
|cellular response to hepatocyte growth factor stimulus|
|branching involved in salivary gland morphogenesis|
|preganglionic parasympathetic fiber development|
|anatomical structure arrangement|
|retina vasculature development in camera-type eye|
|response to hepatocyte growth factor|
|retinal ganglion cell axon guidance|
|positive regulation of actin cytoskeleton reorganization|
|parasympathetic nervous system development|
|blastoderm segmentation|
|kidney vasculature development|
|renal system vasculature development|
|vascular endothelial growth factor signaling pathway|
|positive regulation of cell migration involved in sprouting angiogenesis|
|cell migration involved in sprouting angiogenesis|
|sympathetic nervous system development|
|hypothalamus development|
|neuron projection fasciculation|
|axonal fasciculation|
|regulation of receptor binding|
|positive regulation of focal adhesion assembly|
|negative regulation of axon extension involved in axon guidance|
|innervation|
|substrate-dependent cell migration|
|motor neuron axon guidance|
|negative regulation of axon guidance|
|branching involved in blood vessel morphogenesis|
|outflow tract septum morphogenesis|
|cranial nerve morphogenesis|
|salivary gland morphogenesis|
|blood vessel endothelial cell migration|
|positive regulation of filopodium assembly|
|forebrain neuron development|
|positive regulation of adherens junction organization|
|regulation of axon extension involved in axon guidance|
|growth factor binding|
|salivary gland development|
|platelet-derived growth factor receptor signaling pathway|
|positive regulation of cell junction assembly|
|positive regulation of signaling receptor activity|
|axon extension|
|coreceptor activity|
|semaphorin-plexin signaling pathway|
|regulation of actin cytoskeleton reorganization|
|positive regulation of smooth muscle cell migration|
|positive regulation of substrate adhesion-dependent cell spreading|
|regulation of cell migration involved in sprouting angiogenesis|
|toxin transport|
|positive regulation of sprouting angiogenesis|
|cytokine binding|
|cellular response to vascular endothelial growth factor stimulus|
|negative regulation of axon extension|
|positive regulation of axon extension|
|cerebral cortex cell migration|
|exocrine system development|
|regulation of axon guidance|
|integral component of postsynaptic membrane|
|regulation of filopodium assembly|
|coronary vasculature development|
|autonomic nervous system development|
|neuron recognition|
|positive chemotaxis|
|positive regulation of stress fiber assembly|
|positive regulation of cell-matrix adhesion|
|forebrain neuron differentiation|
|cranial nerve development|
|substrate adhesion-dependent cell spreading|
|regulation of substrate adhesion-dependent cell spreading|
|neural crest cell migration|
|positive regulation of blood vessel endothelial cell migration|
|sprouting angiogenesis|
|negative regulation of chemotaxis|
|telencephalon cell migration|
|dendrite morphogenesis|
|regulation of smooth muscle cell migration|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|neuron projection extension|
|forebrain cell migration|
|positive regulation of actin filament bundle assembly|
|artery morphogenesis|
|embryonic pattern specification|
|actin cytoskeleton reorganization|
|endothelial cell migration|
|forebrain generation of neurons|
|regulation of adherens junction organization|
|vascular endothelial growth factor receptor signaling pathway|
|regulation of sprouting angiogenesis|
|negative regulation of axonogenesis|
|outflow tract morphogenesis|
|cardiac septum morphogenesis|
|diencephalon development|
|nerve development|
|neural crest cell development|
|regulation of stress fiber assembly|
|central nervous system neuron development|
|endothelial cell differentiation|
|stem cell development|
|epithelial cell migration|
|mesenchymal cell development|
|positive regulation of axonogenesis|
|artery development|
|epithelium migration|
|postsynapse organization|
|developmental cell growth|
|cell fate specification|
|regulation of actomyosin structure organization|
|neural crest cell differentiation|
|regulation of cell junction assembly|
|regulation of blood vessel endothelial cell migration|
|cell growth|
|regulation of actin filament bundle assembly|
|positive regulation of protein binding|
|positive regulation of endothelial cell proliferation|
|tissue migration|
|integrin-mediated signaling pathway|
|endothelium development|
|segmentation|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|positive regulation of endothelial cell migration|
|gland morphogenesis|
|positive regulation of plasma membrane bounded cell projection assembly|
|negative regulation of extrinsic apoptotic signaling pathway|
|dendrite development|
|negative regulation of developmental growth|
|cardiac septum development|
|limbic system development|
|regulation of extent of cell growth|
|regulation of cell-matrix adhesion|
|developmental growth involved in morphogenesis|
|cerebral cortex development|
|neuron migration|
|positive regulation of cell-substrate adhesion|
|cardiac chamber morphogenesis|
|regulation of endothelial cell proliferation|
|growth cone|
|branching morphogenesis of an epithelial tube|
|positive regulation of chemotaxis|
|retina development in camera-type eye|
|positive regulation of epithelial cell migration|
|regulation of Rho protein signal transduction|
|negative regulation of neuron apoptotic process|
|regulation of extrinsic apoptotic signaling pathway|
|negative regulation of neuron projection development|
|positive regulation of cell morphogenesis involved in differentiation|
|mesenchymal cell differentiation|
|stem cell differentiation|
|regulation of endothelial cell migration|
|morphogenesis of a branching epithelium|
|positive regulation of angiogenesis|
|positive regulation of cell growth|
|morphogenesis of a branching structure|
|heparin binding|
|cardiac chamber development|
|positive regulation of developmental growth|
|ameboidal-type cell migration|
|regulation of signaling receptor activity|
|pallium development|
|positive regulation of binding|
|central nervous system neuron differentiation|
|negative regulation of cell projection organization|
|regulation of cell size|
|negative regulation of cell growth|
|positive regulation of vasculature development|
|cell-substrate adhesion|
|regulation of axonogenesis|
|positive regulation of epithelial cell proliferation|
|positive regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of supramolecular fiber organization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|receptor complex|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|cell chemotaxis|
|regulation of cell-substrate adhesion|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|regulation of protein binding|
|positive regulation of cytoskeleton organization|
|regulation of epithelial cell migration|
|mesenchyme development|
|negative regulation of apoptotic signaling pathway|
|negative regulation of neuron differentiation|
|cell recognition|
|negative regulation of growth|
|regulation of Ras protein signal transduction|
|cell fate commitment|
|heart morphogenesis|
|cytoplasmic vesicle|
|regulation of peptidyl-tyrosine phosphorylation|
|early endosome|
|telencephalon development|
|positive regulation of growth|
|axon guidance|
|regulation of actin filament organization|
|neuron projection guidance|
|kidney development|
|synapse organization|
|positive regulation of neuron projection development|
|GTPase activator activity|
|renal system development|
|regulation of angiogenesis|
|negative regulation of neurogenesis|
|regulation of ERK1 and ERK2 cascade|
|axon|
|regulation of cell morphogenesis involved in differentiation|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|regulation of neuron death|
|negative regulation of nervous system development|
|camera-type eye development|
|angiogenesis|
|urogenital system development|
|neuron projection|
|regulation of vasculature development|
|negative regulation of locomotion|
|regulation of developmental growth|
|regionalization|
|negative regulation of cell development|
|regulation of epithelial cell proliferation|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|glutamatergic synapse|
|regulation of supramolecular fiber organization|
|eye development|
|visual system development|
|negative regulation of response to external stimulus|
|positive regulation of neuron differentiation|
|sensory system development|
|axonogenesis|
|neuronal cell body|
|regulation of cellular component size|
|regulation of binding|
|positive regulation of cell projection organization|
|forebrain development|
|regulation of actin filament-based process|
|developmental growth|
|growth|
|regulation of apoptotic signaling pathway|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|axon development|
|gland development|
|positive regulation of GTPase activity|
|focal adhesion|
|regulation of cell growth|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|pattern specification process|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|protein kinase binding|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|regulation of anatomical structure size|
|cell part morphogenesis|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|sensory organ development|
|regulation of vesicle-mediated transport|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|actin filament-based process|
|response to wounding|
|positive regulation of response to external stimulus|
|cell surface|
|positive regulation of organelle organization|
|tube morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|regulation of cell adhesion|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|protein localization to organelle|
|brain development|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|cytoskeleton organization|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|extracellular space|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11288
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NRP1 Expression in NALM6 Cells: 3.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>