NRP1

Gene Information

Official Symbol: NRP1
Official Name: neuropilin 1
Aliases and Previous Symbols: N/A
Entrez ID: 8829
UniProt: O14786
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11288
Expression level (log2 read counts): 3.08

Expression Distribution

MAM
DUF3481
F5 F8 type C
CUB

positive regulation of cytokine activity
VEGF-activated neuropilin signaling pathway involved in axon guidance
otic placode development
VEGF-activated neuropilin signaling pathway
dorsal root ganglion morphogenesis
endothelial tip cell fate specification
positive regulation of retinal ganglion cell axon guidance
ganglion morphogenesis
renal artery morphogenesis
vestibulocochlear nerve structural organization
blood vessel endothelial cell fate commitment
hypothalamic tangential migration using cell-axon interactions
cerebral cortex tangential migration using cell-axon interactions
angiogenesis involved in coronary vascular morphogenesis
blood vessel endothelial cell fate specification
facioacoustic ganglion development
basal dendrite morphogenesis
protein localization to early endosome
endothelial cell fate specification
sensory neuron axon guidance
gonadotrophin-releasing hormone neuronal migration to the hypothalamus
basal dendrite arborization
basal dendrite development
hypothalamus gonadotrophin-releasing hormone neuron differentiation
regulation of cytokine activity
hypothalamus cell migration
neuropilin signaling pathway
sympathetic neuron projection guidance
trunk neural crest cell migration
ventral trunk neural crest cell migration
sympathetic neuron projection extension
hypothalamus gonadotrophin-releasing hormone neuron development
trunk segmentation
trigeminal ganglion development
trigeminal nerve morphogenesis
trigeminal nerve structural organization
regulation of retinal ganglion cell axon guidance
substrate-dependent cerebral cortex tangential migration
dichotomous subdivision of terminal units involved in salivary gland branching
motor neuron migration