NSUN5 [The Human Chemical-Genetic Interaction Map Project]

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======= NSUN5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NSUN5
  * **<color #00a2e8>Official Name</color>**: NOP2/Sun RNA methyltransferase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55695|55695]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96P11|Q96P11]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NSUN5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NSUN5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615732|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 in 28S rRNA. {ECO:0000305|PubMed:23913415}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nol1 Nop2 Fmu|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rRNA base methylation|
|rRNA methylation|
|rRNA modification|
|methyltransferase activity|
|RNA methylation|
|RNA modification|
|rRNA processing|
|rRNA metabolic process|
|macromolecule methylation|
|ribosome biogenesis|
|methylation|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.84|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.14|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.79|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.76|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.82|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.92|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.95|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.98|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12149
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NSUN5 Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>