NSUN5

Entrez Summary: N/A
UniProt Summary: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 in 28S rRNA. {ECO:0000305|PubMed:23913415}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CR131-b 0.005μM R08 exp474	-2.84
LY2090314 0.003μM R08 exp500 no dilution day6	-2.14
PU-H71 1μM R08 exp515	-1.79
PFI-2 4μM R05 exp239	-1.76
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.82
Cyclosporin-A 3μM R07 exp348	1.92
BN82002 4μM R07 exp340	1.95
VHL-ligand-1 20μM R07 exp421	1.98
5-Azacytidine 2μM R07 exp330	2.31

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

rRNA base methylation
rRNA methylation
rRNA modification
methyltransferase activity
RNA methylation
RNA modification
rRNA processing
rRNA metabolic process
macromolecule methylation
ribosome biogenesis
methylation
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA binding
RNA metabolic process
gene expression