NUBP1 [The Human Chemical-Genetic Interaction Map Project]

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======= NUBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUBP1
  * **<color #00a2e8>Official Name</color>**: nucleotide binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4682|4682]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53384|P53384]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600280|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery (PubMed:18573874). Required for maturation of extramitochondrial Fe-S proteins (PubMed:18573874). The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (PubMed:18573874). Implicated in the regulation of centrosome duplication (By similarity). Negatively regulates cilium formation and structure (By similarity). {ECO:0000250|UniProtKB:Q9R060, ECO:0000269|PubMed:18573874}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MipZ|
|CbiA|
|ParA|
|ArsA ATPase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to cell cortex|
|iron-sulfur cluster binding|
|negative regulation of centrosome duplication|
|negative regulation of centrosome cycle|
|iron-sulfur cluster assembly|
|metallo-sulfur cluster assembly|
|centrosome localization|
|microtubule organizing center localization|
|4 iron, 4 sulfur cluster binding|
|regulation of centrosome duplication|
|regulation of centrosome cycle|
|cellular iron ion homeostasis|
|nucleotide binding|
|iron ion homeostasis|
|cellular transition metal ion homeostasis|
|transition metal ion homeostasis|
|negative regulation of cytoskeleton organization|
|centriole|
|regulation of microtubule cytoskeleton organization|
|cilium|
|cofactor biosynthetic process|
|regulation of microtubule-based process|
|protein localization to cell periphery|
|negative regulation of cell cycle process|
|sulfur compound metabolic process|
|negative regulation of organelle organization|
|regulation of cell growth|
|cofactor metabolic process|
|regulation of cytoskeleton organization|
|cellular metal ion homeostasis|
|negative regulation of cell cycle|
|organelle localization|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of growth|
|negative regulation of cellular component organization|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of cell cycle process|
|ion homeostasis|
|cellular homeostasis|
|chemical homeostasis|
|cell projection organization|
|regulation of cell cycle|
|regulation of organelle organization|
|ATP binding|
|cellular protein localization|
|cellular macromolecule localization|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.52|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.36|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-2.1|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.95|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-1.81|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.77|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-1.74|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 163/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|9/28|
|bone|12/26|
|breast|6/33|
|central nervous system|15/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|7/21|
|liver|8/20|
|lung|13/75|
|lymphocyte|3/16|
|ovary|2/26|
|pancreas|4/24|
|peripheral nervous system|10/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 111
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUBP1 Expression in NALM6 Cells: 4.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>