NUBP1

Entrez Summary: N/A
UniProt Summary: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery (PubMed:18573874). Required for maturation of extramitochondrial Fe-S proteins (PubMed:18573874). The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (PubMed:18573874). Implicated in the regulation of centrosome duplication (By similarity). Negatively regulates cilium formation and structure (By similarity). {ECO:0000250|UniProtKB:Q9R060, ECO:0000269|PubMed:18573874}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CoCl2 18μM R07 exp346	-2.52
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-2.36
Trientine 500μM R08 exp534	-2.1
Deferoxamine 11μM R07 exp350	-1.95
CyclicAMP 200μM R08 exp475	-1.81
All-trans-Retinoic-Acid 40μM R07 exp334	-1.77
GSK-J4 1-1.25μM to day4 R07 exp363	-1.74
Sulforaphane 9μM R08 exp525	-1.72

Global Fraction of Cell Lines Where Essential: 163/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	2/28
blood	9/28
bone	12/26
breast	6/33
central nervous system	15/56
cervix	0/4
colorectal	2/17
esophagus	1/13
fibroblast	0/1
gastric	3/16
kidney	7/21
liver	8/20
lung	13/75
lymphocyte	3/16
ovary	2/26
pancreas	4/24
peripheral nervous system	10/16
plasma cell	5/15
prostate	0/1
skin	4/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	2/29
uterus	2/5

Expression Distribution

protein localization to cell cortex
iron-sulfur cluster binding
negative regulation of centrosome duplication
negative regulation of centrosome cycle
iron-sulfur cluster assembly
metallo-sulfur cluster assembly
centrosome localization
microtubule organizing center localization
4 iron, 4 sulfur cluster binding
regulation of centrosome duplication
regulation of centrosome cycle
cellular iron ion homeostasis
nucleotide binding
iron ion homeostasis
cellular transition metal ion homeostasis
transition metal ion homeostasis
negative regulation of cytoskeleton organization
centriole
regulation of microtubule cytoskeleton organization
cilium
cofactor biosynthetic process
regulation of microtubule-based process
protein localization to cell periphery
negative regulation of cell cycle process
sulfur compound metabolic process
negative regulation of organelle organization
regulation of cell growth
cofactor metabolic process
regulation of cytoskeleton organization
cellular metal ion homeostasis
negative regulation of cell cycle
organelle localization
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
regulation of growth
negative regulation of cellular component organization
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis