NUDT1 [The Human Chemical-Genetic Interaction Map Project]

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======= NUDT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUDT1
  * **<color #00a2e8>Official Name</color>**: nudix hydrolase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4521|4521]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P36639|P36639]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUDT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUDT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600312|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000269|PubMed:10373420, ECO:0000269|PubMed:10608900, ECO:0000269|PubMed:11139615, ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:22556419}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NUDIX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GTP diphosphatase activity|
|ATP diphosphatase activity|
|8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity|
|8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity|
|dGTP catabolic process|
|dATP catabolic process|
|dGTP metabolic process|
|dATP metabolic process|
|DNA protection|
|purine deoxyribonucleoside triphosphate catabolic process|
|purine nucleoside triphosphate catabolic process|
|purine deoxyribonucleotide catabolic process|
|deoxyribonucleoside triphosphate catabolic process|
|purine deoxyribonucleoside triphosphate metabolic process|
|purine deoxyribonucleotide metabolic process|
|m7G(5)pppN diphosphatase activity|
|nucleoside triphosphate catabolic process|
|snoRNA binding|
|deoxyribonucleoside triphosphate metabolic process|
|deoxyribonucleotide catabolic process|
|deoxyribose phosphate catabolic process|
|2-deoxyribonucleotide metabolic process|
|deoxyribose phosphate metabolic process|
|deoxyribonucleotide metabolic process|
|purine nucleotide catabolic process|
|nucleobase-containing small molecule catabolic process|
|purine-containing compound catabolic process|
|response to cadmium ion|
|nucleotide catabolic process|
|purine nucleoside triphosphate metabolic process|
|nucleoside phosphate catabolic process|
|acrosomal vesicle|
|nucleoside triphosphate metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|organophosphate catabolic process|
|male gonad development|
|development of primary male sexual characteristics|
|male sex differentiation|
|carbohydrate derivative catabolic process|
|gonad development|
|development of primary sexual characteristics|
|nuclear membrane|
|cellular response to extracellular stimulus|
|sex differentiation|
|aging|
|GTPase activity|
|purine nucleotide metabolic process|
|cellular response to external stimulus|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|response to metal ion|
|nucleobase-containing compound catabolic process|
|response to oxidative stress|
|reproductive structure development|
|reproductive system development|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|DNA repair|
|response to extracellular stimulus|
|response to inorganic substance|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|developmental process involved in reproduction|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|reproductive process|
|reproduction|
|extracellular space|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.97|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.11|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.35|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.55|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.68|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.74|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|3.15|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|3.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12491
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUDT1 Expression in NALM6 Cells: 4.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>