NUDT1

Entrez Summary: N/A
UniProt Summary: Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000269|PubMed:10373420, ECO:0000269|PubMed:10608900, ECO:0000269|PubMed:11139615, ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:22556419}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GTP diphosphatase activity
ATP diphosphatase activity
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
dGTP catabolic process
dATP catabolic process
dGTP metabolic process
dATP metabolic process
DNA protection
purine deoxyribonucleoside triphosphate catabolic process
purine nucleoside triphosphate catabolic process
purine deoxyribonucleotide catabolic process
deoxyribonucleoside triphosphate catabolic process
purine deoxyribonucleoside triphosphate metabolic process
purine deoxyribonucleotide metabolic process
m7G(5)pppN diphosphatase activity
nucleoside triphosphate catabolic process
snoRNA binding
deoxyribonucleoside triphosphate metabolic process
deoxyribonucleotide catabolic process
deoxyribose phosphate catabolic process
2-deoxyribonucleotide metabolic process
deoxyribose phosphate metabolic process
deoxyribonucleotide metabolic process
purine nucleotide catabolic process
nucleobase-containing small molecule catabolic process
purine-containing compound catabolic process
response to cadmium ion
nucleotide catabolic process
purine nucleoside triphosphate metabolic process
nucleoside phosphate catabolic process
acrosomal vesicle
nucleoside triphosphate metabolic process
nucleobase-containing small molecule biosynthetic process
organophosphate catabolic process
male gonad development
development of primary male sexual characteristics
male sex differentiation
carbohydrate derivative catabolic process
gonad development