NUDT9

Entrez Summary: The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'- phosphate.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ADP catabolic process
IDP catabolic process
ADP-sugar diphosphatase activity
IDP metabolic process
adenosine-diphosphatase activity
purine nucleoside diphosphate catabolic process
purine ribonucleoside diphosphate catabolic process
ribonucleoside diphosphate catabolic process
ADP-ribose diphosphatase activity
nucleoside diphosphate catabolic process
purine ribonucleotide catabolic process
ribonucleotide catabolic process
purine nucleotide catabolic process
ADP metabolic process
nucleobase-containing small molecule catabolic process
purine-containing compound catabolic process
purine nucleoside diphosphate metabolic process
purine ribonucleoside diphosphate metabolic process
ribonucleoside diphosphate metabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process
nucleoside diphosphate metabolic process
nucleobase-containing small molecule biosynthetic process
organophosphate catabolic process
carbohydrate derivative catabolic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
mitochondrial matrix
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process