NUTF2 [The Human Chemical-Genetic Interaction Map Project]

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======= NUTF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUTF2
  * **<color #00a2e8>Official Name</color>**: nuclear transport factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10204|10204]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61970|P61970]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUTF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUTF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605813|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. {ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:7744965}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NTF2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of vascular endothelial growth factor production|
|protein localization to nuclear pore|
|nuclear pore central transport channel|
|protein localization to nuclear envelope|
|nuclear import signal receptor activity|
|nuclear outer membrane|
|structural constituent of nuclear pore|
|regulation of vascular endothelial growth factor production|
|Ran GTPase binding|
|positive regulation of protein import into nucleus|
|positive regulation of protein import|
|nuclear inner membrane|
|regulation of protein import into nucleus|
|regulation of protein import|
|positive regulation of nucleocytoplasmic transport|
|positive regulation of protein localization to nucleus|
|protein import into nucleus|
|regulation of nucleocytoplasmic transport|
|import into nucleus|
|regulation of protein localization to nucleus|
|protein import|
|protein export from nucleus|
|positive regulation of intracellular protein transport|
|mRNA transport|
|nuclear export|
|protein localization to nucleus|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|positive regulation of intracellular transport|
|RNA localization|
|regulation of intracellular protein transport|
|nuclear membrane|
|nucleobase-containing compound transport|
|nucleocytoplasmic transport|
|nuclear transport|
|negative regulation of cytokine production|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|positive regulation of protein transport|
|establishment of protein localization to organelle|
|positive regulation of establishment of protein localization|
|regulation of cellular protein localization|
|regulation of cytokine production|
|regulation of protein transport|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cellular localization|
|positive regulation of transport|
|intracellular protein transport|
|regulation of protein localization|
|identical protein binding|
|negative regulation of multicellular organismal process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.25|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.08|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-2.02|
|[[:results:exp302|35°C R06 exp302]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 666/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|28/28|
|blood|27/28|
|bone|25/26|
|breast|30/33|
|central nervous system|50/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|11/13|
|fibroblast|0/1|
|gastric|15/16|
|kidney|19/21|
|liver|20/20|
|lung|66/75|
|lymphocyte|15/16|
|ovary|24/26|
|pancreas|20/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|8/9|
|thyroid|1/2|
|upper aerodigestive|17/22|
|urinary tract|26/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 229
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUTF2 Expression in NALM6 Cells: 6.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>