NUTF2

Entrez Summary: N/A
UniProt Summary: Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. {ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:7744965}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 666/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	28/28
blood	27/28
bone	25/26
breast	30/33
central nervous system	50/56
cervix	4/4
colorectal	13/17
esophagus	11/13
fibroblast	0/1
gastric	15/16
kidney	19/21
liver	20/20
lung	66/75
lymphocyte	15/16
ovary	24/26
pancreas	20/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	22/24
soft tissue	8/9
thyroid	1/2
upper aerodigestive	17/22
urinary tract	26/29
uterus	5/5

Expression Distribution

negative regulation of vascular endothelial growth factor production
protein localization to nuclear pore
nuclear pore central transport channel
protein localization to nuclear envelope
nuclear import signal receptor activity
nuclear outer membrane
structural constituent of nuclear pore
regulation of vascular endothelial growth factor production
Ran GTPase binding
positive regulation of protein import into nucleus
positive regulation of protein import
nuclear inner membrane
regulation of protein import into nucleus
regulation of protein import
positive regulation of nucleocytoplasmic transport
positive regulation of protein localization to nucleus
protein import into nucleus
regulation of nucleocytoplasmic transport
import into nucleus
regulation of protein localization to nucleus
protein import
protein export from nucleus
positive regulation of intracellular protein transport
mRNA transport
nuclear export
protein localization to nucleus
nucleic acid transport
RNA transport
establishment of RNA localization
positive regulation of intracellular transport
RNA localization
regulation of intracellular protein transport
nuclear membrane
nucleobase-containing compound transport
nucleocytoplasmic transport
nuclear transport
negative regulation of cytokine production
positive regulation of cellular protein localization
regulation of intracellular transport
positive regulation of protein transport