NXN

Entrez Summary: N/A
UniProt Summary: Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

AhpC-TSA
Redoxin

protein-disulfide reductase activity
thioredoxin-disulfide reductase activity
negative regulation of protein ubiquitination
cell redox homeostasis
negative regulation of protein modification by small protein conjugation or removal
cellular oxidant detoxification
cellular detoxification
detoxification
regulation of protein ubiquitination
negative regulation of Wnt signaling pathway
cellular response to toxic substance
regulation of protein modification by small protein conjugation or removal
Wnt signaling pathway
cell-cell signaling by wnt
regulation of Wnt signaling pathway
in utero embryonic development
cell surface receptor signaling pathway involved in cell-cell signaling
response to toxic substance
cardiovascular system development
negative regulation of protein modification process
chordate embryonic development
embryo development ending in birth or egg hatching
circulatory system development
cellular homeostasis
oxidation-reduction process
embryo development
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
cell-cell signaling
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
negative regulation of response to stimulus
homeostatic process
regulation of protein modification process