OAZ3

Entrez Summary: N/A
UniProt Summary: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity). {ECO:0000250|UniProtKB:Q9R109, ECO:0000269|PubMed:17900240}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

putrescine transmembrane transporter activity
putrescine transport
negative regulation of polyamine transmembrane transport
polyamine transport
ornithine decarboxylase inhibitor activity
regulation of polyamine transmembrane transport
polyamine biosynthetic process
polyamine metabolic process
cellular biogenic amine biosynthetic process
amine biosynthetic process
organic cation transport
ammonium transport
cellular biogenic amine metabolic process
cellular amine metabolic process
regulation of cellular amino acid metabolic process
amine metabolic process
regulation of cellular amine metabolic process
negative regulation of transmembrane transport
blood microparticle
regulation of cellular ketone metabolic process
positive regulation of protein catabolic process
regulation of protein catabolic process
regulation of small molecule metabolic process
positive regulation of catabolic process
negative regulation of transport
spermatogenesis
regulation of transmembrane transport
male gamete generation
gamete generation
negative regulation of catalytic activity
multicellular organismal reproductive process
cation transport
sexual reproduction
multicellular organism reproduction
regulation of catabolic process
multi-organism reproductive process
negative regulation of molecular function
ion transport
organonitrogen compound biosynthetic process
reproductive process