OBSCN

Official Symbol: OBSCN
Official Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Aliases and Previous Symbols: N/A
Entrez ID: 84033
UniProt: Q5VST9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein localization to M-band
titin binding
phosphatidylinositol-5-phosphate binding
ankyrin binding
M band
myofibril
phosphatidylinositol-3,4-bisphosphate binding
phosphatidylinositol-4-phosphate binding
phosphatidylinositol-3,4,5-trisphosphate binding
phosphatidylinositol-3-phosphate binding
sarcomere organization
structural constituent of muscle
myofibril assembly
Rho guanyl-nucleotide exchange factor activity
phosphatidylinositol-4,5-bisphosphate binding
sarcolemma
cellular component assembly involved in morphogenesis
actomyosin structure organization
Z disc
striated muscle cell development
regulation of Rho protein signal transduction
muscle cell development
striated muscle cell differentiation
calmodulin binding
regulation of Ras protein signal transduction
muscle cell differentiation
nuclear body
regulation of small GTPase mediated signal transduction
protein serine/threonine kinase activity
supramolecular fiber organization
muscle structure development
actin cytoskeleton organization
actin filament-based process
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
protein localization to organelle
organelle assembly
cellular component morphogenesis
anatomical structure formation involved in morphogenesis