OCRL [The Human Chemical-Genetic Interaction Map Project]

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======= OCRL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OCRL
  * **<color #00a2e8>Official Name</color>**: OCRL inositol polyphosphate-5-phosphatase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4952|4952]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01968|Q01968]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OCRL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OCRL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300535|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RhoGAP|
|Exo endo phos|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inositol phosphate phosphatase activity|
|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|
|inositol phosphate dephosphorylation|
|phosphorylated carbohydrate dephosphorylation|
|inositol phosphate catabolic process|
|Golgi-associated vesicle|
|phosphatidylinositol dephosphorylation|
|polyol catabolic process|
|phospholipid dephosphorylation|
|Golgi stack|
|Rac GTPase binding|
|clathrin-coated pit|
|alcohol catabolic process|
|clathrin-coated vesicle|
|inositol phosphate metabolic process|
|photoreceptor outer segment|
|phagocytic vesicle membrane|
|organic hydroxy compound catabolic process|
|phosphatidylinositol biosynthetic process|
|polyol metabolic process|
|organophosphate catabolic process|
|early endosome membrane|
|phosphatidylinositol metabolic process|
|trans-Golgi network|
|cellular carbohydrate metabolic process|
|lipid modification|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|early endosome|
|GTPase activator activity|
|glycerophospholipid metabolic process|
|dephosphorylation|
|alcohol metabolic process|
|regulation of small GTPase mediated signal transduction|
|cilium assembly|
|cilium organization|
|phospholipid metabolic process|
|in utero embryonic development|
|glycerolipid metabolic process|
|positive regulation of GTPase activity|
|small molecule catabolic process|
|plasma membrane bounded cell projection assembly|
|organic hydroxy compound metabolic process|
|cell projection assembly|
|carbohydrate metabolic process|
|regulation of GTPase activity|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|organelle assembly|
|positive regulation of hydrolase activity|
|membrane organization|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|embryo development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|lipid metabolic process|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.8|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16579
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OCRL Expression in NALM6 Cells: 4.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>