OCRL

Entrez Summary: This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
Doxorubicin 0.02μM R08 exp478	1.8
CVT-10216 0.1μM R06 exp278	1.82

RhoGAP
Exo endo phos

inositol phosphate phosphatase activity
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
inositol phosphate dephosphorylation
phosphorylated carbohydrate dephosphorylation
inositol phosphate catabolic process
Golgi-associated vesicle
phosphatidylinositol dephosphorylation
polyol catabolic process
phospholipid dephosphorylation
Golgi stack
Rac GTPase binding
clathrin-coated pit
alcohol catabolic process
clathrin-coated vesicle
inositol phosphate metabolic process
photoreceptor outer segment
phagocytic vesicle membrane
organic hydroxy compound catabolic process
phosphatidylinositol biosynthetic process
polyol metabolic process
organophosphate catabolic process
early endosome membrane
phosphatidylinositol metabolic process
trans-Golgi network
cellular carbohydrate metabolic process
lipid modification
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
early endosome
GTPase activator activity
glycerophospholipid metabolic process
dephosphorylation
alcohol metabolic process
regulation of small GTPase mediated signal transduction
cilium assembly
cilium organization
phospholipid metabolic process
in utero embryonic development
glycerolipid metabolic process