OCSTAMP

Gene Information

Official Symbol: OCSTAMP
Official Name: osteoclast stimulatory transmembrane protein
Aliases and Previous Symbols: N/A
Entrez ID: 128506
UniProt: Q9BR26
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4054
Expression level (log2 read counts): -2.47

Expression Distribution

positive regulation of osteoclast proliferation
regulation of osteoclast proliferation
positive regulation of macrophage fusion
regulation of macrophage fusion
multinuclear osteoclast differentiation
cellular response to estrogen stimulus
positive regulation of osteoclast differentiation
positive regulation of syncytium formation by plasma membrane fusion
regulation of syncytium formation by plasma membrane fusion
osteoclast differentiation
positive regulation of myeloid leukocyte differentiation
regulation of osteoclast differentiation
response to estrogen
positive regulation of myeloid cell differentiation
myeloid leukocyte differentiation
regulation of myeloid leukocyte differentiation
positive regulation of leukocyte proliferation
positive regulation of leukocyte differentiation
positive regulation of hemopoiesis
myeloid cell differentiation
regulation of leukocyte proliferation
regulation of myeloid cell differentiation
cellular response to tumor necrosis factor
response to tumor necrosis factor
regulation of leukocyte differentiation
leukocyte differentiation
regulation of hemopoiesis
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
positive regulation of cell population proliferation
positive regulation of cell differentiation
cellular response to cytokine stimulus
regulation of anatomical structure morphogenesis
response to cytokine
positive regulation of immune system process
positive regulation of cellular component organization
positive regulation of developmental process
regulation of cell population proliferation
regulation of immune system process