OPCML
Gene Information
- Official Symbol: OPCML
- Official Name: opioid binding protein/cell adhesion molecule like
- Aliases and Previous Symbols: N/A
- Entrez ID: 4978
- UniProt: Q14982
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
- UniProt Summary: Binds opioids in the presence of acidic lipids; probably involved in cell contact.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14505
- Expression level (log2 read counts): -2.6
OPCML Expression in NALM6 Cells: -2.6
