OPLAH

Entrez Summary: The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD). [provided by RefSeq, Jun 2012].
UniProt Summary: Catalyzes the cleavage of 5-oxo-L-proline to form L- glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

5-oxoprolinase (ATP-hydrolyzing) activity
glutathione biosynthetic process
nonribosomal peptide biosynthetic process
cellular modified amino acid biosynthetic process
glutathione metabolic process
sulfur compound biosynthetic process
cellular modified amino acid metabolic process
cofactor biosynthetic process
sulfur compound metabolic process
peptide biosynthetic process
cofactor metabolic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process