ORMDL2

Entrez Summary: N/A
UniProt Summary: Negative regulator of sphingolipid synthesis. {ECO:0000269|PubMed:20182505}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
UNC1999 2μM R03 exp155	-1.91
Cyclosporin-A 3μM R07 exp348	2.23

SPOTS complex
cellular sphingolipid homeostasis
negative regulation of sphingolipid biosynthetic process
negative regulation of ceramide biosynthetic process
regulation of sphingolipid biosynthetic process
regulation of membrane lipid metabolic process
regulation of ceramide biosynthetic process
negative regulation of lipid biosynthetic process
negative regulation of lipid metabolic process
ceramide metabolic process
lipid homeostasis
negative regulation of cellular amide metabolic process
sphingolipid metabolic process
regulation of lipid biosynthetic process
membrane lipid metabolic process
regulation of lipid metabolic process
regulation of cellular amide metabolic process
cellular chemical homeostasis
cellular amide metabolic process
cellular homeostasis
cellular lipid metabolic process
regulation of cellular component biogenesis
endoplasmic reticulum
chemical homeostasis
lipid metabolic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
homeostatic process