OSCAR

Entrez Summary: N/A
UniProt Summary: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

collagen receptor activity
collagen-activated signaling pathway
osteoclast differentiation
tertiary granule lumen
specific granule lumen
myeloid leukocyte differentiation
myeloid cell differentiation
leukocyte differentiation
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
hemopoiesis
myeloid leukocyte activation
hematopoietic or lymphoid organ development
leukocyte activation involved in immune response
cell activation involved in immune response
immune system development
regulated exocytosis
leukocyte mediated immunity
exocytosis
leukocyte activation
secretion by cell
export from cell
cell activation
immune effector process
secretion
regulation of immune response
regulation of immune system process
immune response
extracellular region
vesicle-mediated transport