OVGP1

Entrez Summary: This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008].
UniProt Summary: Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

perivitelline space
egg coat
negative regulation of binding of sperm to zona pellucida
chitin metabolic process
chitin catabolic process
regulation of binding of sperm to zona pellucida
chitinase activity
negative regulation of fertilization
chitin binding
glucosamine-containing compound catabolic process
amino sugar catabolic process
glucosamine-containing compound metabolic process
regulation of fertilization
binding of sperm to zona pellucida
amino sugar metabolic process
sperm-egg recognition
negative regulation of reproductive process
aminoglycan catabolic process
cell-cell recognition
transport vesicle
single fertilization
drug catabolic process
regulation of reproductive process
aminoglycan metabolic process
fertilization
female pregnancy
carbohydrate derivative catabolic process
multi-multicellular organism process
negative regulation of multi-organism process
cell recognition
carbohydrate metabolic process
drug metabolic process
regulation of multi-organism process
sexual reproduction
multi-organism reproductive process
carbohydrate derivative metabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
reproductive process
reproduction