OVOL1
Gene Information
- Official Symbol: OVOL1
- Official Name: ovo like transcriptional repressor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5017
- UniProt: O14753
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| germline cell cycle switching, mitotic to meiotic cell cycle |
| cell cycle switching |
| negative regulation of meiotic cell cycle phase transition |
| cell cycle switching, mitotic to meiotic cell cycle |
| regulation of meiotic cell cycle phase transition |
| negative regulation of stem cell proliferation |
| negative regulation of meiotic cell cycle |
| positive regulation of meiotic cell cycle |
| regulation of meiotic cell cycle |
| negative regulation of reproductive process |
| regulation of stem cell proliferation |
| positive regulation of reproductive process |
| mesoderm development |
| regulation of reproductive process |
| negative regulation of cell cycle phase transition |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| kidney development |
| renal system development |
| negative regulation of mitotic cell cycle |
| epidermal cell differentiation |
| urogenital system development |
| negative regulation of cell cycle process |
| positive regulation of cell cycle |
| skin development |
| epidermis development |
| sequence-specific DNA binding |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| regulation of cell cycle phase transition |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| spermatogenesis |
| male gamete generation |
| negative regulation of cell cycle |
| regulation of mitotic cell cycle |
| negative regulation of cell population proliferation |
| epithelial cell differentiation |
| gamete generation |
| regulation of cell cycle process |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| negative regulation of transcription by RNA polymerase II |
| multi-organism reproductive process |
| cell cycle process |
| epithelium development |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| cell cycle |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Tunicamycin 0.04μM R07 exp418 | -1.71 |
| Ibrutinib 10μM R08 exp442 | 1.77 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18702
- Expression level (log2 read counts): -5.6
Expression Distribution
OVOL1 Expression in NALM6 Cells: -5.6