OXCT1

Entrez Summary: This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008].
UniProt Summary: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

3-oxoacid CoA-transferase activity
ketone body catabolic process
ketone catabolic process
cellular ketone body metabolic process
fatty acid derivative catabolic process
ketone body metabolic process
positive regulation of insulin secretion involved in cellular response to glucose stimulus
adipose tissue development
regulation of insulin secretion involved in cellular response to glucose stimulus
response to activity
cellular ketone metabolic process
positive regulation of insulin secretion
positive regulation of peptide hormone secretion
response to ethanol
positive regulation of hormone secretion
drug catabolic process
fatty acid derivative metabolic process
regulation of insulin secretion
response to starvation
regulation of peptide hormone secretion
response to nutrient
connective tissue development
response to alcohol
regulation of hormone secretion
positive regulation of protein secretion
positive regulation of peptide secretion
response to antibiotic
mitochondrial matrix
positive regulation of secretion by cell
generation of precursor metabolites and energy
positive regulation of protein transport
positive regulation of secretion
small molecule catabolic process
positive regulation of establishment of protein localization
regulation of protein secretion
regulation of peptide secretion
response to nutrient levels
drug metabolic process
response to toxic substance
heart development