OXT
Gene Information
- Official Symbol: OXT
- Official Name: oxytocin/neurophysin I prepropeptide
- Aliases and Previous Symbols: N/A
- Entrez ID: 5020
- UniProt: P01178
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Neurophysin 1 specifically binds oxytocin.
Pfam Domains GO Terms
Pfam Domains
| Hormone 5 |
GO Terms
| positive regulation of hindgut contraction |
| oxytocin receptor binding |
| neurohypophyseal hormone activity |
| regulation of hindgut contraction |
| positive regulation of female receptivity |
| positive regulation of norepinephrine secretion |
| maternal aggressive behavior |
| sperm ejaculation |
| positive regulation of penile erection |
| negative regulation of urine volume |
| male mating behavior |
| response to disaccharide |
| response to sucrose |
| positive regulation of uterine smooth muscle contraction |
| negative regulation of gastric acid secretion |
| regulation of penile erection |
| regulation of female receptivity |
| aggressive behavior |
| female mating behavior |
| hyperosmotic salinity response |
| drinking behavior |
| positive regulation of prostaglandin secretion |
| positive regulation of digestive system process |
| regulation of uterine smooth muscle contraction |
| regulation of prostaglandin secretion |
| insemination |
| regulation of gastric acid secretion |
| response to ether |
| positive regulation of catecholamine secretion |
| maternal behavior |
| parental behavior |
| sleep |
| positive regulation of renal sodium excretion |
| grooming behavior |
| copulation |
| regulation of norepinephrine secretion |
| positive regulation of icosanoid secretion |
| positive regulation of fatty acid transport |
| negative regulation of digestive system process |
| regulation of icosanoid secretion |
| regulation of renal sodium excretion |
| mating behavior |
| response to food |
| regulation of urine volume |
| response to prostaglandin E |
| response to salt stress |
| regulation of excretion |
| hyperosmotic response |
| regulation of fatty acid transport |
| neuropeptide hormone activity |
| eating behavior |
| reproductive behavior |
| response to prostaglandin |
| positive regulation of smooth muscle contraction |
| response to amphetamine |
| mating |
| positive regulation of organic acid transport |
| regulation of renal system process |
| positive regulation of amine transport |
| positive regulation of blood pressure |
| regulation of sensory perception of pain |
| regulation of digestive system process |
| regulation of sensory perception |
| response to electrical stimulus |
| positive regulation of muscle contraction |
| negative regulation of blood pressure |
| response to progesterone |
| response to amine |
| terminal bouton |
| positive regulation of anion transport |
| response to bronchodilator |
| social behavior |
| intraspecies interaction between organisms |
| response to cocaine |
| regulation of organic acid transport |
| regulation of smooth muscle contraction |
| positive regulation of lipid transport |
| regulation of catecholamine secretion |
| response to activity |
| positive regulation of synapse assembly |
| multi-organism behavior |
| response to osmotic stress |
| positive regulation of reproductive process |
| response to anesthetic |
| positive regulation of lipid localization |
| positive regulation of ossification |
| response to fatty acid |
| feeding behavior |
| secretory granule |
| regulation of amine transport |
| regulation of anion transport |
| regulation of heart rate |
| positive regulation of cold-induced thermogenesis |
| response to cAMP |
| regulation of synapse assembly |
| regulation of lipid transport |
| response to retinoic acid |
| renal system process |
| response to alkaloid |
| memory |
| response to estradiol |
| response to organophosphorus |
| regulation of nervous system process |
| regulation of lipid localization |
| regulation of cold-induced thermogenesis |
| response to glucocorticoid |
| positive regulation of synaptic transmission |
| response to purine-containing compound |
| regulation of muscle contraction |
| regulation of reproductive process |
| response to corticosteroid |
| response to carbohydrate |
| female pregnancy |
| regulation of blood pressure |
| response to ammonium ion |
| regulation of ossification |
| response to ketone |
| multi-multicellular organism process |
| regulation of synapse organization |
| regulation of synapse structure or activity |
| negative regulation of secretion |
| response to alcohol |
| regulation of muscle system process |
| regulation of heart contraction |
| learning or memory |
| positive regulation of ion transport |
| positive regulation of cytosolic calcium ion concentration |
| regulation of blood circulation |
| cognition |
| response to xenobiotic stimulus |
| regulation of cytosolic calcium ion concentration |
| response to steroid hormone |
| response to acid chemical |
| blood circulation |
| response to peptide hormone |
| circulatory system process |
| positive regulation of secretion by cell |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| response to peptide |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| regulation of body fluid levels |
| response to nutrient levels |
| response to toxic substance |
| positive regulation of multi-organism process |
| positive regulation of cellular component biogenesis |
| heart development |
| response to extracellular stimulus |
| positive regulation of nervous system development |
| cellular metal ion homeostasis |
| behavior |
| regulation of system process |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| regulation of secretion by cell |
| regulation of multi-organism process |
| ion homeostasis |
| regulation of secretion |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| response to lipid |
| circulatory system development |
| cellular homeostasis |
| response to hormone |
| response to organic cyclic compound |
| regulation of nervous system development |
| regulation of cellular component biogenesis |
| positive regulation of transport |
| multi-organism reproductive process |
| response to organonitrogen compound |
| response to drug |
| response to nitrogen compound |
| chemical homeostasis |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| G protein-coupled receptor signaling pathway |
| positive regulation of developmental process |
| nervous system process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| extracellular space |
| homeostatic process |
| positive regulation of multicellular organismal process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
| extracellular region |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9214
- Expression level (log2 read counts): -7.68
Expression Distribution
OXT Expression in NALM6 Cells: -7.68
