P2RX2
Gene Information
- Official Symbol: P2RX2
- Official Name: purinergic receptor P2X 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 22953
- UniProt: Q9UBL9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| P2X receptor |
GO Terms
| detection of hypoxic conditions in blood by carotid body chemoreceptor signaling |
| regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling |
| regulation of systemic arterial blood pressure by chemoreceptor signaling |
| detection of hypoxic conditions in blood by chemoreceptor signaling |
| urinary bladder smooth muscle contraction |
| extracellularly ATP-gated cation channel activity |
| ATP-gated ion channel activity |
| urinary tract smooth muscle contraction |
| purinergic nucleotide receptor activity |
| peristalsis |
| nervous system process involved in regulation of systemic arterial blood pressure |
| ligand-gated ion channel activity |
| behavioral response to pain |
| integral component of nuclear inner membrane |
| phasic smooth muscle contraction |
| purinergic nucleotide receptor signaling pathway |
| skeletal muscle fiber development |
| myotube cell development |
| purinergic receptor signaling pathway |
| response to pain |
| response to ATP |
| neuromuscular synaptic transmission |
| neuromuscular junction development |
| positive regulation of calcium-mediated signaling |
| response to ischemia |
| smooth muscle contraction |
| positive regulation of calcium ion transport into cytosol |
| myotube differentiation |
| muscle fiber development |
| excitatory postsynaptic potential |
| chemical synaptic transmission, postsynaptic |
| sensory perception of taste |
| multicellular organismal response to stress |
| postsynapse |
| regulation of systemic arterial blood pressure |
| regulation of calcium-mediated signaling |
| regulation of calcium ion transport into cytosol |
| regulation of postsynaptic membrane potential |
| positive regulation of calcium ion transport |
| skeletal muscle tissue development |
| skeletal muscle organ development |
| striated muscle cell development |
| response to organophosphorus |
| sensory perception of sound |
| muscle cell development |
| response to purine-containing compound |
| sensory perception of mechanical stimulus |
| response to carbohydrate |
| regulation of blood pressure |
| striated muscle cell differentiation |
| receptor complex |
| response to nutrient |
| muscle cell differentiation |
| regulation of calcium ion transport |
| muscle contraction |
| synapse organization |
| positive regulation of ion transport |
| positive regulation of cytosolic calcium ion concentration |
| striated muscle tissue development |
| blood coagulation |
| coagulation |
| muscle organ development |
| muscle tissue development |
| hemostasis |
| muscle system process |
| apical plasma membrane |
| regulation of cytosolic calcium ion concentration |
| protein homooligomerization |
| response to hypoxia |
| response to decreased oxygen levels |
| neuronal cell body |
| response to oxygen levels |
| regulation of metal ion transport |
| blood circulation |
| circulatory system process |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of membrane potential |
| cellular calcium ion homeostasis |
| trans-synaptic signaling |
| calcium ion homeostasis |
| synaptic signaling |
| cellular divalent inorganic cation homeostasis |
| muscle structure development |
| wound healing |
| divalent inorganic cation homeostasis |
| regulation of body fluid levels |
| response to nutrient levels |
| protein complex oligomerization |
| detection of chemical stimulus |
| response to extracellular stimulus |
| sensory perception of chemical stimulus |
| cellular metal ion homeostasis |
| behavior |
| response to wounding |
| cation transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| detection of stimulus |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| ion homeostasis |
| cation transport |
| cellular homeostasis |
| regulation of cellular localization |
| response to organic cyclic compound |
| ion transmembrane transport |
| sensory perception |
| positive regulation of transport |
| response to organonitrogen compound |
| response to drug |
| positive regulation of intracellular signal transduction |
| identical protein binding |
| response to nitrogen compound |
| chemical homeostasis |
| cell-cell signaling |
| response to abiotic stimulus |
| transmembrane transport |
| ion transport |
| nervous system process |
| integral component of plasma membrane |
| ATP binding |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| tissue development |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| protein-containing complex subunit organization |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2910
- Expression level (log2 read counts): -1.2
Expression Distribution
P2RX2 Expression in NALM6 Cells: -1.2
