P2RX7 [The Human Chemical-Genetic Interaction Map Project]

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======= P2RX7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: P2RX7
  * **<color #00a2e8>Official Name</color>**: purinergic receptor P2X 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5027|5027]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99572|Q99572]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=P2RX7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20P2RX7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602566|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|P2X receptor|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phospholipid transfer to membrane|
|regulation of bleb assembly|
|positive regulation of bleb assembly|
|NAD transport|
|positive regulation of interleukin-1 alpha secretion|
|positive regulation of gamma-aminobutyric acid secretion|
|calcium-mediated signaling using extracellular calcium source|
|regulation of interleukin-1 alpha secretion|
|positive regulation of interleukin-1 alpha production|
|negative regulation of cell volume|
|regulation of interleukin-1 alpha production|
|regulation of gamma-aminobutyric acid secretion|
|purinergic nucleotide receptor activity|
|extracellularly ATP-gated cation channel activity|
|ATP-gated ion channel activity|
|coenzyme transport|
|bleb|
|positive regulation of mitochondrial depolarization|
|positive regulation of glutamate secretion|
|bleb assembly|
|positive regulation of prostaglandin secretion|
|positive regulation of cytolysis|
|regulation of prostaglandin secretion|
|positive regulation of membrane depolarization|
|negative regulation of bone resorption|
|phagolysosome assembly|
|negative regulation of bone remodeling|
|regulation of glutamate secretion|
|integral component of nuclear inner membrane|
|positive regulation of icosanoid secretion|
|regulation of cytolysis|
|regulation of killing of cells of other organism|
|positive regulation of amino acid transport|
|cellular response to ATP|
|plasma membrane phospholipid scrambling|
|positive regulation of lymphocyte apoptotic process|
|positive regulation of fatty acid transport|
|regulation of icosanoid secretion|
|negative regulation of tissue remodeling|
|purinergic nucleotide receptor signaling pathway|
|regulation of mitochondrial depolarization|
|pore complex assembly|
|cellular response to dsRNA|
|membrane protein ectodomain proteolysis|
|positive regulation of glycolytic process|
|nucleotide transport|
|positive regulation of T cell mediated cytotoxicity|
|regulation of fatty acid transport|
|cell volume homeostasis|
|positive regulation of leukocyte apoptotic process|
|purinergic receptor signaling pathway|
|homeostasis of number of cells within a tissue|
|regulation of amino acid transport|
|response to ATP|
|positive regulation of interleukin-1 beta secretion|
|T cell homeostasis|
|regulation of T cell mediated cytotoxicity|
|positive regulation of organic acid transport|
|response to fluid shear stress|
|lipopolysaccharide binding|
|positive regulation of amine transport|
|membrane protein proteolysis|
|positive regulation of interleukin-1 secretion|
|T cell proliferation|
|positive regulation of neurotransmitter transport|
|positive regulation of bone mineralization|
|regulation of bone resorption|
|response to electrical stimulus|
|phagosome maturation|
|phospholipid translocation|
|lipid translocation|
|regulation of membrane depolarization|
|positive regulation of purine nucleotide metabolic process|
|positive regulation of ATP metabolic process|
|positive regulation of nucleotide metabolic process|
|cofactor transport|
|positive regulation of biomineralization|
|positive regulation of biomineral tissue development|
|regulation of interleukin-1 beta secretion|
|ceramide biosynthetic process|
|positive regulation of T cell mediated immunity|
|regulation of bone remodeling|
|response to ischemia|
|positive regulation of anion transport|
|regulation of membrane lipid distribution|
|membrane depolarization|
|positive regulation of interleukin-1 beta production|
|regulation of lymphocyte apoptotic process|
|response to dsRNA|
|lymphocyte homeostasis|
|regulation of interleukin-1 secretion|
|positive regulation of calcium ion transport into cytosol|
|response to zinc ion|
|release of sequestered calcium ion into cytosol|
|positive regulation of leukocyte mediated cytotoxicity|
|negative regulation of sequestering of calcium ion|
|regulation of organic acid transport|
|positive regulation of interleukin-1 production|
|lysosome organization|
|lytic vacuole organization|
|positive regulation of lipid transport|
|excitatory postsynaptic potential|
|synaptic vesicle exocytosis|
|collagen metabolic process|
|positive regulation of cell killing|
|cellular response to nutrient|
|calcium ion transmembrane import into cytosol|
|chemical synaptic transmission, postsynaptic|
|leukocyte homeostasis|
|regulation of mitochondrial membrane potential|
|regulation of T cell mediated immunity|
|regulation of tissue remodeling|
|calcium ion transport into cytosol|
|sensory perception of pain|
|regulation of bone mineralization|
|neuromuscular junction|
|regulation of leukocyte mediated cytotoxicity|
|regulation of glycolytic process|
|positive regulation of carbohydrate metabolic process|
|positive regulation of lipid localization|
|regulation of interleukin-1 beta production|
|regulation of leukocyte apoptotic process|
|lymphocyte proliferation|
|ceramide metabolic process|
|postsynapse|
|positive regulation of ossification|
|mononuclear cell proliferation|
|regulation of sodium ion transport|
|regulation of carbohydrate catabolic process|
|cytosolic calcium ion transport|
|sphingolipid biosynthetic process|
|phospholipid transport|
|plasma membrane organization|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|regulation of amine transport|
|defense response to Gram-positive bacterium|
|presynapse|
|positive regulation of interleukin-6 production|
|regulation of interleukin-1 production|
|regulation of anion transport|
|extrinsic apoptotic signaling pathway|
|vesicle budding from membrane|
|leukocyte proliferation|
|regulation of calcium ion transport into cytosol|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of postsynaptic membrane potential|
|positive regulation of plasma membrane bounded cell projection assembly|
|regulation of cell killing|
|signal release from synapse|
|neurotransmitter secretion|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|regulation of lipid transport|
|reactive oxygen species metabolic process|
|regulation of purine nucleotide metabolic process|
|synaptic vesicle cycle|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|positive regulation of calcium ion transport|
|organophosphate ester transport|
|regulation of sequestering of calcium ion|
|vacuole organization|
|vesicle-mediated transport in synapse|
|membrane lipid biosynthetic process|
|positive regulation of leukocyte mediated immunity|
|response to organophosphorus|
|regulation of lipid localization|
|positive regulation of small molecule metabolic process|
|positive regulation of cytokine secretion|
|regulation of interleukin-6 production|
|regulation of neurotransmitter transport|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|calcium-mediated signaling|
|regulation of lymphocyte mediated immunity|
|response to calcium ion|
|response to purine-containing compound|
|sphingolipid metabolic process|
|activation of MAPK activity|
|positive regulation of ion transmembrane transport|
|protein processing|
|regulation of generation of precursor metabolites and energy|
|regulation of adaptive immune response|
|negative regulation of MAPK cascade|
|signal release|
|cell-cell junction|
|neurotransmitter transport|
|regulation of cell size|
|regulation of ossification|
|tissue homeostasis|
|calcium ion transmembrane transport|
|regulation of plasma membrane bounded cell projection assembly|
|homeostasis of number of cells|
|regulation of cell projection assembly|
|positive regulation of transmembrane transport|
|membrane lipid metabolic process|
|regulation of carbohydrate metabolic process|
|regulation of cytokine secretion|
|regulation of leukocyte mediated immunity|
|response to mechanical stimulus|
|response to nutrient|
|positive regulation of immune effector process|
|positive regulation of cytoskeleton organization|
|protein maturation|
|cellular response to nutrient levels|
|T cell activation|
|skeletal system morphogenesis|
|nucleobase-containing compound transport|
|regulation of calcium ion transport|
|calcium ion transport|
|positive regulation of MAP kinase activity|
|cellular response to extracellular stimulus|
|positive regulation of protein secretion|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|apoptotic signaling pathway|
|positive regulation of peptide secretion|
|blood coagulation|
|coagulation|
|divalent metal ion transport|
|hemostasis|
|lipid transport|
|vesicle organization|
|divalent inorganic cation transport|
|response to lipopolysaccharide|
|lipid localization|
|multicellular organismal homeostasis|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|activation of protein kinase activity|
|phagocytosis|
|defense response to bacterium|
|cellular response to external stimulus|
|signaling receptor binding|
|second-messenger-mediated signaling|
|positive regulation of protein serine/threonine kinase activity|
|anatomical structure homeostasis|
|regulation of MAP kinase activity|
|regulation of neurotransmitter levels|
|positive regulation of cellular catabolic process|
|response to metal ion|
|neuronal cell body|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|lymphocyte activation|
|regulation of metal ion transport|
|external side of plasma membrane|
|positive regulation of secretion by cell|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|endomembrane system organization|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|positive regulation of protein transport|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of small molecule metabolic process|
|regulation of membrane potential|
|positive regulation of catabolic process|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|mitochondrion organization|
|negative regulation of phosphorylation|
|plasma membrane bounded cell projection assembly|
|calcium ion homeostasis|
|positive regulation of cytokine production|
|cell projection assembly|
|organic anion transport|
|positive regulation of establishment of protein localization|
|synaptic signaling|
|regulation of protein secretion|
|regulation of immune effector process|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|wound healing|
|divalent inorganic cation homeostasis|
|skeletal system development|
|regulation of peptide secretion|
|regulation of body fluid levels|
|response to nutrient levels|
|inflammatory response|
|negative regulation of intracellular signal transduction|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|amide biosynthetic process|
|response to extracellular stimulus|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|cell population proliferation|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|response to wounding|
|positive regulation of kinase activity|
|lipid biosynthetic process|
|anion transport|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|cation transmembrane transport|
|positive regulation of organelle organization|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|protein catabolic process|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of ion transport|
|regulated exocytosis|
|cation homeostasis|
|regulation of protein transport|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|cell morphogenesis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|organelle assembly|
|regulation of multi-organism process|
|cellular amide metabolic process|
|ion homeostasis|
|exocytosis|
|regulation of protein kinase activity|
|regulation of secretion|
|cellular component morphogenesis|
|cation transport|
|regulation of cellular catabolic process|
|membrane organization|
|response to lipid|
|positive regulation of immune response|
|regulation of kinase activity|
|protein homodimerization activity|
|cellular homeostasis|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|leukocyte activation|
|ion transmembrane transport|
|defense response to other organism|
|cellular lipid metabolic process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|sensory perception|
|protein phosphorylation|
|regulation of transferase activity|
|positive regulation of transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|export from cell|
|macromolecule catabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|cell activation|
|response to nitrogen compound|
|cell death|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|proteolysis|
|transmembrane transport|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|vesicle-mediated transport|
|system process|
|positive regulation of gene expression|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.81|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7350
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='P2RX7 Expression in NALM6 Cells: 3.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>