P2RX7
Gene Information
- Official Symbol: P2RX7
- Official Name: purinergic receptor P2X 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 5027
- UniProt: Q99572
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| P2X receptor |
GO Terms
| phospholipid transfer to membrane |
| regulation of bleb assembly |
| positive regulation of bleb assembly |
| NAD transport |
| positive regulation of interleukin-1 alpha secretion |
| positive regulation of gamma-aminobutyric acid secretion |
| calcium-mediated signaling using extracellular calcium source |
| regulation of interleukin-1 alpha secretion |
| positive regulation of interleukin-1 alpha production |
| negative regulation of cell volume |
| regulation of interleukin-1 alpha production |
| regulation of gamma-aminobutyric acid secretion |
| purinergic nucleotide receptor activity |
| extracellularly ATP-gated cation channel activity |
| ATP-gated ion channel activity |
| coenzyme transport |
| bleb |
| positive regulation of mitochondrial depolarization |
| positive regulation of glutamate secretion |
| bleb assembly |
| positive regulation of prostaglandin secretion |
| positive regulation of cytolysis |
| regulation of prostaglandin secretion |
| positive regulation of membrane depolarization |
| negative regulation of bone resorption |
| phagolysosome assembly |
| negative regulation of bone remodeling |
| regulation of glutamate secretion |
| integral component of nuclear inner membrane |
| positive regulation of icosanoid secretion |
| regulation of cytolysis |
| regulation of killing of cells of other organism |
| positive regulation of amino acid transport |
| cellular response to ATP |
| plasma membrane phospholipid scrambling |
| positive regulation of lymphocyte apoptotic process |
| positive regulation of fatty acid transport |
| regulation of icosanoid secretion |
| negative regulation of tissue remodeling |
| purinergic nucleotide receptor signaling pathway |
| regulation of mitochondrial depolarization |
| pore complex assembly |
| cellular response to dsRNA |
| membrane protein ectodomain proteolysis |
| positive regulation of glycolytic process |
| nucleotide transport |
| positive regulation of T cell mediated cytotoxicity |
| regulation of fatty acid transport |
| cell volume homeostasis |
| positive regulation of leukocyte apoptotic process |
| purinergic receptor signaling pathway |
| homeostasis of number of cells within a tissue |
| regulation of amino acid transport |
| response to ATP |
| positive regulation of interleukin-1 beta secretion |
| T cell homeostasis |
| regulation of T cell mediated cytotoxicity |
| positive regulation of organic acid transport |
| response to fluid shear stress |
| lipopolysaccharide binding |
| positive regulation of amine transport |
| membrane protein proteolysis |
| positive regulation of interleukin-1 secretion |
| T cell proliferation |
| positive regulation of neurotransmitter transport |
| positive regulation of bone mineralization |
| regulation of bone resorption |
| response to electrical stimulus |
| phagosome maturation |
| phospholipid translocation |
| lipid translocation |
| regulation of membrane depolarization |
| positive regulation of purine nucleotide metabolic process |
| positive regulation of ATP metabolic process |
| positive regulation of nucleotide metabolic process |
| cofactor transport |
| positive regulation of biomineralization |
| positive regulation of biomineral tissue development |
| regulation of interleukin-1 beta secretion |
| ceramide biosynthetic process |
| positive regulation of T cell mediated immunity |
| regulation of bone remodeling |
| response to ischemia |
| positive regulation of anion transport |
| regulation of membrane lipid distribution |
| membrane depolarization |
| positive regulation of interleukin-1 beta production |
| regulation of lymphocyte apoptotic process |
| response to dsRNA |
| lymphocyte homeostasis |
| regulation of interleukin-1 secretion |
| positive regulation of calcium ion transport into cytosol |
| response to zinc ion |
| release of sequestered calcium ion into cytosol |
| positive regulation of leukocyte mediated cytotoxicity |
| negative regulation of sequestering of calcium ion |
| regulation of organic acid transport |
| positive regulation of interleukin-1 production |
| lysosome organization |
| lytic vacuole organization |
| positive regulation of lipid transport |
| excitatory postsynaptic potential |
| synaptic vesicle exocytosis |
| collagen metabolic process |
| positive regulation of cell killing |
| cellular response to nutrient |
| calcium ion transmembrane import into cytosol |
| chemical synaptic transmission, postsynaptic |
| leukocyte homeostasis |
| regulation of mitochondrial membrane potential |
| regulation of T cell mediated immunity |
| regulation of tissue remodeling |
| calcium ion transport into cytosol |
| sensory perception of pain |
| regulation of bone mineralization |
| neuromuscular junction |
| regulation of leukocyte mediated cytotoxicity |
| regulation of glycolytic process |
| positive regulation of carbohydrate metabolic process |
| positive regulation of lipid localization |
| regulation of interleukin-1 beta production |
| regulation of leukocyte apoptotic process |
| lymphocyte proliferation |
| ceramide metabolic process |
| postsynapse |
| positive regulation of ossification |
| mononuclear cell proliferation |
| regulation of sodium ion transport |
| regulation of carbohydrate catabolic process |
| cytosolic calcium ion transport |
| sphingolipid biosynthetic process |
| phospholipid transport |
| plasma membrane organization |
| regulation of biomineralization |
| regulation of biomineral tissue development |
| regulation of amine transport |
| defense response to Gram-positive bacterium |
| presynapse |
| positive regulation of interleukin-6 production |
| regulation of interleukin-1 production |
| regulation of anion transport |
| extrinsic apoptotic signaling pathway |
| vesicle budding from membrane |
| leukocyte proliferation |
| regulation of calcium ion transport into cytosol |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of postsynaptic membrane potential |
| positive regulation of plasma membrane bounded cell projection assembly |
| regulation of cell killing |
| signal release from synapse |
| neurotransmitter secretion |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of adaptive immune response |
| regulation of lipid transport |
| reactive oxygen species metabolic process |
| regulation of purine nucleotide metabolic process |
| synaptic vesicle cycle |
| regulation of nucleotide metabolic process |
| regulation of ATP metabolic process |
| positive regulation of calcium ion transport |
| organophosphate ester transport |
| regulation of sequestering of calcium ion |
| vacuole organization |
| vesicle-mediated transport in synapse |
| membrane lipid biosynthetic process |
| positive regulation of leukocyte mediated immunity |
| response to organophosphorus |
| regulation of lipid localization |
| positive regulation of small molecule metabolic process |
| positive regulation of cytokine secretion |
| regulation of interleukin-6 production |
| regulation of neurotransmitter transport |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| calcium-mediated signaling |
| regulation of lymphocyte mediated immunity |
| response to calcium ion |
| response to purine-containing compound |
| sphingolipid metabolic process |
| activation of MAPK activity |
| positive regulation of ion transmembrane transport |
| protein processing |
| regulation of generation of precursor metabolites and energy |
| regulation of adaptive immune response |
| negative regulation of MAPK cascade |
| signal release |
| cell-cell junction |
| neurotransmitter transport |
| regulation of cell size |
| regulation of ossification |
| tissue homeostasis |
| calcium ion transmembrane transport |
| regulation of plasma membrane bounded cell projection assembly |
| homeostasis of number of cells |
| regulation of cell projection assembly |
| positive regulation of transmembrane transport |
| membrane lipid metabolic process |
| regulation of carbohydrate metabolic process |
| regulation of cytokine secretion |
| regulation of leukocyte mediated immunity |
| response to mechanical stimulus |
| response to nutrient |
| positive regulation of immune effector process |
| positive regulation of cytoskeleton organization |
| protein maturation |
| cellular response to nutrient levels |
| T cell activation |
| skeletal system morphogenesis |
| nucleobase-containing compound transport |
| regulation of calcium ion transport |
| calcium ion transport |
| positive regulation of MAP kinase activity |
| cellular response to extracellular stimulus |
| positive regulation of protein secretion |
| positive regulation of ion transport |
| positive regulation of cytosolic calcium ion concentration |
| apoptotic signaling pathway |
| positive regulation of peptide secretion |
| blood coagulation |
| coagulation |
| divalent metal ion transport |
| hemostasis |
| lipid transport |
| vesicle organization |
| divalent inorganic cation transport |
| response to lipopolysaccharide |
| lipid localization |
| multicellular organismal homeostasis |
| response to molecule of bacterial origin |
| regulation of cytosolic calcium ion concentration |
| activation of protein kinase activity |
| phagocytosis |
| defense response to bacterium |
| cellular response to external stimulus |
| signaling receptor binding |
| second-messenger-mediated signaling |
| positive regulation of protein serine/threonine kinase activity |
| anatomical structure homeostasis |
| regulation of MAP kinase activity |
| regulation of neurotransmitter levels |
| positive regulation of cellular catabolic process |
| response to metal ion |
| neuronal cell body |
| regulation of cellular component size |
| positive regulation of cell projection organization |
| lymphocyte activation |
| regulation of metal ion transport |
| external side of plasma membrane |
| positive regulation of secretion by cell |
| cellular response to drug |
| negative regulation of protein phosphorylation |
| endomembrane system organization |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| positive regulation of protein transport |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of small molecule metabolic process |
| regulation of membrane potential |
| positive regulation of catabolic process |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| trans-synaptic signaling |
| mitochondrion organization |
| negative regulation of phosphorylation |
| plasma membrane bounded cell projection assembly |
| calcium ion homeostasis |
| positive regulation of cytokine production |
| cell projection assembly |
| organic anion transport |
| positive regulation of establishment of protein localization |
| synaptic signaling |
| regulation of protein secretion |
| regulation of immune effector process |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| wound healing |
| divalent inorganic cation homeostasis |
| skeletal system development |
| regulation of peptide secretion |
| regulation of body fluid levels |
| response to nutrient levels |
| inflammatory response |
| negative regulation of intracellular signal transduction |
| regulation of anatomical structure size |
| regulation of protein serine/threonine kinase activity |
| protein complex oligomerization |
| positive regulation of cellular component biogenesis |
| amide biosynthetic process |
| response to extracellular stimulus |
| positive regulation of protein kinase activity |
| response to inorganic substance |
| regulation of cytoskeleton organization |
| cellular response to organic cyclic compound |
| positive regulation of MAPK cascade |
| cell population proliferation |
| cellular metal ion homeostasis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| inorganic cation transmembrane transport |
| regulation of transmembrane transport |
| response to wounding |
| positive regulation of kinase activity |
| lipid biosynthetic process |
| anion transport |
| negative regulation of protein modification process |
| cellular response to organonitrogen compound |
| cation transmembrane transport |
| positive regulation of organelle organization |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| positive regulation of programmed cell death |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| protein catabolic process |
| response to bacterium |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cytokine production |
| positive regulation of cell death |
| regulation of ion transport |
| regulated exocytosis |
| cation homeostasis |
| regulation of protein transport |
| regulation of cell projection organization |
| inorganic ion homeostasis |
| cell morphogenesis |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| organelle assembly |
| regulation of multi-organism process |
| cellular amide metabolic process |
| ion homeostasis |
| exocytosis |
| regulation of protein kinase activity |
| regulation of secretion |
| cellular component morphogenesis |
| cation transport |
| regulation of cellular catabolic process |
| membrane organization |
| response to lipid |
| positive regulation of immune response |
| regulation of kinase activity |
| protein homodimerization activity |
| cellular homeostasis |
| regulation of cellular localization |
| response to organic cyclic compound |
| apoptotic process |
| leukocyte activation |
| ion transmembrane transport |
| defense response to other organism |
| cellular lipid metabolic process |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| sensory perception |
| protein phosphorylation |
| regulation of transferase activity |
| positive regulation of transport |
| regulation of catabolic process |
| response to organonitrogen compound |
| secretion by cell |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| export from cell |
| macromolecule catabolic process |
| programmed cell death |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| organonitrogen compound catabolic process |
| cell activation |
| response to nitrogen compound |
| cell death |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| cell projection organization |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| proteolysis |
| transmembrane transport |
| phosphorylation |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| ion transport |
| nervous system process |
| integral component of plasma membrane |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| ATP binding |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| vesicle-mediated transport |
| system process |
| positive regulation of gene expression |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Cytochalasin-B 5μM R07 exp349 | -1.81 |
| DKK1 89ng/ml R08 exp477 | 1.97 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7350
- Expression level (log2 read counts): 3.98
Expression Distribution
P2RX7 Expression in NALM6 Cells: 3.98
