P2RY4 [The Human Chemical-Genetic Interaction Map Project]

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======= P2RY4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: P2RY4
  * **<color #00a2e8>Official Name</color>**: pyrimidinergic receptor P2Y4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5030|5030]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51582|P51582]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=P2RY4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20P2RY4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300038|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|uridine nucleotide receptor activity|
|UTP-activated nucleotide receptor activity|
|transepithelial chloride transport|
|G protein-coupled purinergic nucleotide receptor activity|
|G protein-coupled purinergic nucleotide receptor signaling pathway|
|integral component of presynaptic active zone membrane|
|cellular response to prostaglandin E stimulus|
|regulation of presynaptic cytosolic calcium ion concentration|
|cellular response to ATP|
|transepithelial transport|
|G protein-coupled purinergic receptor signaling pathway|
|purinergic nucleotide receptor signaling pathway|
|cellular response to prostaglandin stimulus|
|response to prostaglandin E|
|purinergic receptor signaling pathway|
|response to prostaglandin|
|response to ATP|
|neuron cellular homeostasis|
|cellular response to fatty acid|
|cellular response to nutrient|
|regulation of synaptic vesicle exocytosis|
|response to fatty acid|
|cellular response to alcohol|
|cellular response to ketone|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|chloride transport|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|response to organophosphorus|
|regulation of neurotransmitter transport|
|response to purine-containing compound|
|inorganic anion transport|
|regulation of regulated secretory pathway|
|response to ketone|
|basolateral plasma membrane|
|cellular response to acid chemical|
|response to nutrient|
|regulation of exocytosis|
|response to alcohol|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|positive regulation of cytosolic calcium ion concentration|
|apical plasma membrane|
|regulation of cytosolic calcium ion concentration|
|cellular response to external stimulus|
|anatomical structure homeostasis|
|response to acid chemical|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|cellular response to drug|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|response to nutrient levels|
|cellular response to lipid|
|response to extracellular stimulus|
|cellular response to organic cyclic compound|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|anion transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|ion transport|
|integral component of plasma membrane|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|homeostatic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.82|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17741
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='P2RY4 Expression in NALM6 Cells: -3.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>