P2RY4

Entrez Summary: The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
Palbociclib 1μM R07 exp382	-1.82
CFI-400945 25μM R08 exp469	1.99

uridine nucleotide receptor activity
UTP-activated nucleotide receptor activity
transepithelial chloride transport
G protein-coupled purinergic nucleotide receptor activity
G protein-coupled purinergic nucleotide receptor signaling pathway
integral component of presynaptic active zone membrane
cellular response to prostaglandin E stimulus
regulation of presynaptic cytosolic calcium ion concentration
cellular response to ATP
transepithelial transport
G protein-coupled purinergic receptor signaling pathway
purinergic nucleotide receptor signaling pathway
cellular response to prostaglandin stimulus
response to prostaglandin E
purinergic receptor signaling pathway
response to prostaglandin
response to ATP
neuron cellular homeostasis
cellular response to fatty acid
cellular response to nutrient
regulation of synaptic vesicle exocytosis
response to fatty acid
cellular response to alcohol
cellular response to ketone
phospholipase C-activating G protein-coupled receptor signaling pathway
chloride transport
regulation of neurotransmitter secretion
regulation of synaptic vesicle cycle
response to organophosphorus
regulation of neurotransmitter transport
response to purine-containing compound
inorganic anion transport
regulation of regulated secretory pathway
response to ketone
basolateral plasma membrane
cellular response to acid chemical
response to nutrient
regulation of exocytosis
response to alcohol
cellular response to nutrient levels