P4HA1

Entrez Summary: N/A
UniProt Summary: Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

2OG-FeII Oxy
P4Ha N

procollagen-proline 4-dioxygenase complex
procollagen-proline 4-dioxygenase activity
peptidyl-proline hydroxylation to 4-hydroxy-L-proline
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
peptidyl-proline hydroxylation
4-hydroxyproline metabolic process
L-ascorbic acid binding
protein hydroxylation
collagen fibril organization
peptidyl-proline modification
iron ion binding
cellular modified amino acid metabolic process
alpha-amino acid metabolic process
endoplasmic reticulum lumen
cellular amino acid metabolic process
extracellular matrix organization
extracellular structure organization
supramolecular fiber organization
intracellular membrane-bounded organelle
peptidyl-amino acid modification
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
endoplasmic reticulum
organic acid metabolic process
identical protein binding
mitochondrion
small molecule metabolic process
protein-containing complex subunit organization
membrane