P4HTM

Entrez Summary: N/A
UniProt Summary: Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. {ECO:0000269|PubMed:17726031}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

procollagen-proline 4-dioxygenase activity
peptidyl-proline hydroxylation to 4-hydroxy-L-proline
peptidyl-proline hydroxylation
4-hydroxyproline metabolic process
2-oxoglutarate-dependent dioxygenase activity
L-ascorbic acid binding
protein hydroxylation
regulation of erythrocyte differentiation
peptidyl-proline modification
iron ion binding
cellular modified amino acid metabolic process
alpha-amino acid metabolic process
regulation of myeloid cell differentiation
cellular amino acid metabolic process
regulation of hemopoiesis
calcium ion binding
peptidyl-amino acid modification
carboxylic acid metabolic process
endoplasmic reticulum membrane
oxidation-reduction process
oxoacid metabolic process
endoplasmic reticulum
organic acid metabolic process
regulation of immune system process
small molecule metabolic process
regulation of cell differentiation