PACSIN3

Entrez Summary: N/A
UniProt Summary: Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11082044}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

calcium channel inhibitor activity
positive regulation of membrane protein ectodomain proteolysis
plasma membrane tubulation
regulation of membrane protein ectodomain proteolysis
negative regulation of endocytosis
negative regulation of calcium ion transport
cytoskeletal protein binding
plasma membrane organization
phospholipid binding
negative regulation of ion transport
lipid binding
regulation of endocytosis
positive regulation of protein catabolic process
regulation of calcium ion transport
positive regulation of proteolysis
positive regulation of cellular catabolic process
cytoskeleton
regulation of protein catabolic process
regulation of metal ion transport
endomembrane system organization
positive regulation of catabolic process
negative regulation of transport
regulation of vesicle-mediated transport
endocytosis
import into cell
regulation of ion transport
negative regulation of cellular component organization
regulation of proteolysis
regulation of cellular catabolic process
membrane organization
regulation of catabolic process
cytoskeleton organization
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
regulation of transport
vesicle-mediated transport