PAPPA2

Entrez Summary: This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010].
UniProt Summary: Metalloproteinase which specifically cleaves insulin- like growth factor binding protein (IGFBP)-5 at the '163-Ser-|- Lys-164' bond. Shows limited proteolysis toward IGFBP-3. {ECO:0000269|PubMed:11264294}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Notch
Peptidase M43

response to salt stress
metallopeptidase activity
response to osmotic stress
bone morphogenesis
bone development
skeletal system morphogenesis
apical plasma membrane
regulation of cell growth
skeletal system development
regulation of growth
zinc ion binding
animal organ morphogenesis
response to abiotic stimulus
proteolysis
extracellular region