PAQR3

Gene Information

Official Symbol: PAQR3
Official Name: progestin and adipoQ receptor family member 3
Aliases and Previous Symbols: N/A
Entrez ID: 152559
UniProt: Q6TCH7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017].
UniProt Summary: Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi. {ECO:0000269|PubMed:18547165}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15517
Expression level (log2 read counts): 5.54

Expression Distribution

negative regulation of peptidyl-serine phosphorylation
protein localization to Golgi apparatus
negative regulation of MAP kinase activity
negative regulation of protein serine/threonine kinase activity
regulation of peptidyl-serine phosphorylation
negative regulation of neuron projection development
negative regulation of MAPK cascade
negative regulation of cell projection organization
signaling receptor activity
negative regulation of protein kinase activity
negative regulation of neuron differentiation
negative regulation of kinase activity
negative regulation of transferase activity
negative regulation of neurogenesis
negative regulation of nervous system development
negative regulation of cell development
regulation of MAP kinase activity
MAPK cascade
signal transduction by protein phosphorylation
negative regulation of protein phosphorylation
negative regulation of phosphorylation
regulation of neuron projection development
negative regulation of intracellular signal transduction
regulation of protein serine/threonine kinase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
Golgi membrane
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization
negative regulation of cell differentiation
protein localization to organelle
regulation of MAPK cascade
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of neurogenesis
regulation of kinase activity
regulation of nervous system development