PARP11

Entrez Summary: N/A
UniProt Summary: Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity (PubMed:25673562). {ECO:0000250|UniProtKB:Q8CFF0, ECO:0000269|PubMed:25673562}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

WWE
PARP

protein mono-ADP-ribosylation
protein auto-ADP-ribosylation
protein ADP-ribosylase activity
NAD+ ADP-ribosyltransferase activity
protein ADP-ribosylation
nuclear envelope organization
nuclear pore
nucleus organization
mRNA transport
nuclear envelope
nucleic acid transport
RNA transport
establishment of RNA localization
RNA localization
nucleobase-containing compound transport
endomembrane system organization
spermatogenesis
male gamete generation
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
membrane organization
multi-organism reproductive process
reproductive process
reproduction
protein transport
peptide transport
amide transport
establishment of protein localization
nitrogen compound transport