PARP16

Gene Information

Official Symbol: PARP16
Official Name: poly(ADP-ribose) polymerase family member 16
Aliases and Previous Symbols: N/A
Entrez ID: 54956
UniProt: Q8N5Y8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono- ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine, cysteine or glutamate residues compared to other mono-ADP- ribosyltransferases (PubMed:22701565). {ECO:0000269|PubMed:22701565, ECO:0000269|PubMed:23103912}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13523
Expression level (log2 read counts): 4.11

Expression Distribution

protein auto-ADP-ribosylation
protein mono-ADP-ribosylation
endoplasmic reticulum tubular network
NAD biosynthesis via nicotinamide riboside salvage pathway
protein ADP-ribosylase activity
NAD+ ADP-ribosyltransferase activity
NAD biosynthetic process
protein serine/threonine kinase activator activity
protein ADP-ribosylation
nicotinamide nucleotide biosynthetic process
pyridine nucleotide biosynthetic process
pyridine nucleotide metabolic process
nicotinamide nucleotide metabolic process
pyridine-containing compound biosynthetic process
pyridine-containing compound metabolic process
oxidoreduction coenzyme metabolic process
IRE1-mediated unfolded protein response
kinase binding
response to leukemia inhibitory factor
cellular response to leukemia inhibitory factor
endoplasmic reticulum unfolded protein response
cellular response to unfolded protein
coenzyme biosynthetic process
cellular response to topologically incorrect protein
response to unfolded protein
nuclear envelope
response to topologically incorrect protein
cofactor biosynthetic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
coenzyme metabolic process
response to endoplasmic reticulum stress
positive regulation of protein serine/threonine kinase activity
cofactor metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process