PAWR

Gene Information

Official Symbol: PAWR
Official Name: pro-apoptotic WT1 regulator
Aliases and Previous Symbols: N/A
Entrez ID: 5074
UniProt: Q96IZ0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. {ECO:0000269|PubMed:11585763}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14662
Expression level (log2 read counts): 3.08

Expression Distribution

interleukin-2 biosynthetic process
positive regulation of amyloid precursor protein biosynthetic process
positive regulation of hydrogen peroxide-mediated programmed cell death
positive regulation of hydrogen peroxide-induced cell death
positive regulation of response to reactive oxygen species
regulation of hydrogen peroxide-mediated programmed cell death
interleukin-2 production
positive regulation of cellular response to drug
leucine zipper domain binding
regulation of amyloid precursor protein biosynthetic process
positive regulation of cellular senescence
cytokine biosynthetic process
positive regulation of oxidative stress-induced cell death
positive regulation of cell aging
cytokine metabolic process
negative regulation of B cell proliferation
positive regulation of cellular response to oxidative stress
positive regulation of response to oxidative stress
positive regulation of glycoprotein biosynthetic process
negative regulation of T cell receptor signaling pathway
positive regulation of glycoprotein metabolic process
regulation of hydrogen peroxide-induced cell death
negative regulation of antigen receptor-mediated signaling pathway
negative regulation of fibroblast proliferation
negative regulation of B cell activation
positive regulation of response to drug
regulation of response to reactive oxygen species
regulation of cellular response to drug
regulation of T cell receptor signaling pathway
regulation of glycoprotein biosynthetic process
regulation of cellular senescence
regulation of glycoprotein metabolic process
regulation of cell aging
negative regulation of T cell proliferation
regulation of B cell proliferation
regulation of antigen receptor-mediated signaling pathway
actin filament bundle assembly
regulation of oxidative stress-induced cell death
actin filament bundle organization
negative regulation of lymphocyte proliferation