PAX2

Gene Information

Official Symbol: PAX2
Official Name: paired box 2
Aliases and Previous Symbols: N/A
Entrez ID: 5076
UniProt: Q02962
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014].
UniProt Summary: Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS. {ECO:0000269|PubMed:24676634}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12521
Expression level (log2 read counts): -4.6

Expression Distribution

Screen	Score
Nicotinamide 2000μM R01 exp50	-1.78
Chloroquine 32μM R08 exp470	1.71
Arsenic trioxide 60μM R08 exp449	2.11

PAX
Pax2 C

optic chiasma development
positive regulation of optic nerve formation
regulation of optic nerve formation
regulation of metanephric DCT cell differentiation
negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
positive regulation of metanephric DCT cell differentiation
regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
pattern specification involved in pronephros development
negative regulation of apoptotic process involved in metanephric collecting duct development
regulation of apoptotic process involved in metanephric nephron tubule development
kidney field specification
optic nerve structural organization
regulation of apoptotic process involved in metanephric collecting duct development
negative regulation of apoptotic process involved in metanephric nephron tubule development
regulation of metanephros size
pronephric field specification
negative regulation of mesenchymal cell apoptotic process involved in metanephros development
kidney rudiment formation
regulation of mesenchymal cell apoptotic process involved in metanephros development
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
retinal pigment epithelium development
regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
metanephric nephron tubule formation
negative regulation of somatic stem cell population maintenance
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
ureter maturation
metanephric mesenchymal cell differentiation
distal convoluted tubule development
negative regulation of cytolysis
vestibulocochlear nerve formation
nephric duct formation
regulation of kidney size
positive regulation of metanephric glomerulus development
metanephric distal convoluted tubule development
negative regulation of apoptotic process involved in development
metanephric tubule formation
regulation of metanephric glomerulus development
negative regulation of apoptotic process involved in morphogenesis
regulation of somatic stem cell population maintenance
optic nerve morphogenesis