PAXBP1 [The Human Chemical-Genetic Interaction Map Project]

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======= PAXBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PAXBP1
  * **<color #00a2e8>Official Name</color>**: PAX3 and PAX7 binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=94104|94104]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5B6|Q9Y5B6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PAXBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PAXBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617621|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GCFC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of myoblast proliferation|
|regulation of myoblast proliferation|
|regulation of skeletal muscle satellite cell proliferation|
|regulation of skeletal muscle cell proliferation|
|positive regulation of histone methylation|
|regulation of histone methylation|
|positive regulation of histone modification|
|positive regulation of chromatin organization|
|regulation of histone modification|
|positive regulation of chromosome organization|
|regulation of chromatin organization|
|muscle organ development|
|transcription factor binding|
|regulation of chromosome organization|
|muscle structure development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|positive regulation of organelle organization|
|DNA-binding transcription factor activity|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of cell population proliferation|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp303|39°C R06 exp303]]|-1.79|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|2.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 619/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|23/28|
|bone|18/26|
|breast|29/33|
|central nervous system|48/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|14/21|
|liver|15/20|
|lung|63/75|
|lymphocyte|14/16|
|ovary|19/26|
|pancreas|23/24|
|peripheral nervous system|15/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|22/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2279
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PAXBP1 Expression in NALM6 Cells: 7.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>