PAXBP1

Gene Information

Official Symbol: PAXBP1
Official Name: PAX3 and PAX7 binding protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 94104
UniProt: Q9Y5B6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 619/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	22/28
blood	23/28
bone	18/26
breast	29/33
central nervous system	48/56
cervix	4/4
colorectal	14/17
esophagus	11/13
fibroblast	1/1
gastric	14/16
kidney	14/21
liver	15/20
lung	63/75
lymphocyte	14/16
ovary	19/26
pancreas	23/24
peripheral nervous system	15/16
plasma cell	11/15
prostate	1/1
skin	19/24
soft tissue	6/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	22/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 2279
Expression level (log2 read counts): 7.89

Expression Distribution

Screen	Score
39°C R06 exp303	-1.79
CFI-400945 25μM R08 exp469	2.49

positive regulation of myoblast proliferation
regulation of myoblast proliferation
regulation of skeletal muscle satellite cell proliferation
regulation of skeletal muscle cell proliferation
positive regulation of histone methylation
regulation of histone methylation
positive regulation of histone modification
positive regulation of chromatin organization
regulation of histone modification
positive regulation of chromosome organization
regulation of chromatin organization
muscle organ development
transcription factor binding
regulation of chromosome organization
muscle structure development
RNA polymerase II proximal promoter sequence-specific DNA binding
positive regulation of organelle organization
DNA-binding transcription factor activity
negative regulation of transcription by RNA polymerase II
positive regulation of cell population proliferation
negative regulation of transcription, DNA-templated
positive regulation of cellular component organization
positive regulation of transcription by RNA polymerase II
positive regulation of protein modification process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
regulation of organelle organization
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
positive regulation of cellular protein metabolic process
regulation of cell population proliferation
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of protein metabolic process
negative regulation of gene expression