PDCL3 [The Human Chemical-Genetic Interaction Map Project]

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======= PDCL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDCL3
  * **<color #00a2e8>Official Name</color>**: phosducin like 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79031|79031]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2J4|Q9H2J4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDCL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDCL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611678|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination. {ECO:0000269|PubMed:15371430, ECO:0000269|PubMed:23792958}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Phosducin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vascular endothelial growth factor receptor 2 binding|
|protein folding chaperone|
|negative regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of cellular protein catabolic process|
|positive regulation of endothelial cell proliferation|
|regulation of endothelial cell proliferation|
|negative regulation of protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of angiogenesis|
|positive regulation of vasculature development|
|positive regulation of epithelial cell proliferation|
|regulation of proteolysis involved in cellular protein catabolic process|
|protein folding|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of angiogenesis|
|negative regulation of catabolic process|
|angiogenesis|
|regulation of vasculature development|
|regulation of epithelial cell proliferation|
|negative regulation of proteolysis|
|regulation of protein catabolic process|
|blood vessel morphogenesis|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|tube morphogenesis|
|viral process|
|regulation of proteolysis|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|apoptotic process|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell death|
|negative regulation of protein metabolic process|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3662
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDCL3 Expression in NALM6 Cells: 4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>