PDCL3

Gene Information

Official Symbol: PDCL3
Official Name: phosducin like 3
Aliases and Previous Symbols: N/A
Entrez ID: 79031
UniProt: Q9H2J4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination. {ECO:0000269|PubMed:15371430, ECO:0000269|PubMed:23792958}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3662
Expression level (log2 read counts): 4.27

Expression Distribution

vascular endothelial growth factor receptor 2 binding
protein folding chaperone
negative regulation of ubiquitin-dependent protein catabolic process
negative regulation of proteolysis involved in cellular protein catabolic process
negative regulation of cellular protein catabolic process
positive regulation of endothelial cell proliferation
regulation of endothelial cell proliferation
negative regulation of protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
positive regulation of angiogenesis
positive regulation of vasculature development
positive regulation of epithelial cell proliferation
regulation of proteolysis involved in cellular protein catabolic process
protein folding
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
regulation of peptidyl-tyrosine phosphorylation
regulation of angiogenesis
negative regulation of catabolic process
angiogenesis
regulation of vasculature development
regulation of epithelial cell proliferation
negative regulation of proteolysis
regulation of protein catabolic process
blood vessel morphogenesis
blood vessel development
vasculature development
cardiovascular system development
tube morphogenesis
viral process
regulation of proteolysis
symbiotic process
interspecies interaction between organisms
regulation of cellular catabolic process
tube development
circulatory system development
anatomical structure formation involved in morphogenesis
positive regulation of cell population proliferation
apoptotic process
regulation of catabolic process