PDE6A

Entrez Summary: This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008].
UniProt Summary: This protein participates in processes of transmission and amplification of the visual signal.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PDEase I
GAF

rhodopsin mediated signaling pathway
3,5-cyclic-GMP phosphodiesterase activity
phototransduction, visible light
photoreceptor disc membrane
regulation of rhodopsin mediated signaling pathway
Wnt signaling pathway, calcium modulating pathway
phototransduction
detection of visible light
detection of light stimulus
cellular response to light stimulus
detection of external stimulus
detection of abiotic stimulus
non-canonical Wnt signaling pathway
retina development in camera-type eye
regulation of G protein-coupled receptor signaling pathway
cellular response to radiation
visual perception
sensory perception of light stimulus
response to light stimulus
camera-type eye development
cellular response to abiotic stimulus
cellular response to environmental stimulus
regulation of cytosolic calcium ion concentration
cell-cell signaling by wnt
Wnt signaling pathway
eye development
visual system development
sensory system development
cell surface receptor signaling pathway involved in cell-cell signaling
cellular calcium ion homeostasis
response to radiation
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
sensory organ development
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
detection of stimulus